Organic compounds -- part of the class 532-570 series – Organic compounds – Rare earth containing
Patent
1995-06-07
1998-09-01
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Rare earth containing
534 16, 424 936, 424 9363, 424 9365, 556 45, 556 49, C07F 500, A61K 4900, C09F 1300
Patent
active
058012281
ABSTRACT:
The invention provides polymeric polychelants containing polymer repeat L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at least 4 carbon atoms between the L linkages it interconnects) or a salt or chelate thereof, with the proviso that where Ch is 2,5-biscarboxymethyl-2,5-diazahex-1,6-diyl, the polychelant is metallated with lanthanide or manganese ions or B provides a carbon chain of at least 10 carbon atoms between the L linkages it interconnects and their salts and chelates. The paramagnetic polychelates of the polychelants of the invention have remarkably high R.sub.1 relaxivities.
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Henrichs Paul Mark
Hollister Kenneth Robert
Keller Kenneth Edmund
Ladd David Lee
Peng Xin
Kelley Lara C.
Kight John
Nycomed Imaging AS
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