Polymeric compounds with sustained anti-tumor activity and a met

Details Polymeric compounds with sustained anti-tumor activity and a met Polymeric compounds with sustained anti-tumor activity and a met

1984-09-17

1985-05-28

Lipman, Bernard

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525366, 525375, 525380, C08F 832

Patent

active

045201625

ABSTRACT:
The novel polymeric compound proposed in the invention has a backbone structure formed of a copolymeric moiety of maleic anhydride and divinyl ether and pendant groups thereon derived from an anthracycline-type anti-tumor agent, e.g. adriamycin and daunomycin, or 1-.beta.-D-arabinofuranosylcytosine bonded to the maleic anhydride units in the backbone structure by forming amide linkages, the remaining anhydride units in the backbone structure being hydrolyzed into free acid form or a salt thereof. Both in vitro and in vivo tests indicate that the anti-tumor active pendant groups in the polymeric compound can be released sustainedly to exhibit the anti-tumor activity with greatly decreased side effects unavoidable when the above mentioned anti-tumor agents as such are administrated to a patient in a relatively large dose.

REFERENCES:
patent: 3941756 (1976-03-01), Hoper et al.
patent: 4182800 (1980-01-01), Ringsdorf et al.
patent: 4309413 (1982-01-01), Fields et al.
patent: 4366294 (1982-12-01), Williams et al.

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