Polymeric carrier for delivery of small interfering RNA

Details Polymeric carrier for delivery of small interfering RNA Polymeric carrier for delivery of small interfering RNA

2006-03-03

2010-06-22

Epps-Smith, Janet L (Department: 1633)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C514S04400A

Reexamination Certificate

active

07740880

ABSTRACT:
A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.

REFERENCES:
patent: 2005/0215497 (2005-09-01), Harel-Bellan et al.
patent: WO02069930 (2002-09-01), None
Futaki et al. Bioconjugate Chemistry, 2001, vol. 12, pp. 1005-1011.
P. A. Wender et al., The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters, 97 Proc. Nat'l Acad. Sci. USA 13003-13008 (2000).
S. Futaki et al., Arginine-rich Peptides, 276 Journal of Biological Chemistry 5836-5840 (2001).
S. Futaki et al., Stearylated Arginine-Rich Peptides: A New Class of Transfection Systems, 12 Bioconjugate Chem 1005-1011 (2001).

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