Polymeric assay film for direct colorimetric detection

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435518, 435531, 435528, 435 71, 435164, 435 4, 435 6, 422 55, 422 57, 422 58, 422 8205, 422 8209, 427 2, 428441, 428442, C12Q 170

Patent

active

06001556&

ABSTRACT:
A lipid bilayer with affinity to an analyte, which directly signals binding by a changes in the light absorption spectra. This novel assay means and method has special applications in the drug development and medical testing fields. Using a spectrometer, the system is easily automated, and a multiple well embodiment allows inexpensive screening and sequential testing. This invention also has applications in industry for feedstock and effluent monitoring.

REFERENCES:
patent: 4859538 (1989-08-01), Ribi
patent: 5268305 (1993-12-01), Ribi et al.
patent: 5415999 (1995-05-01), Saul et al.
patent: 5427915 (1995-06-01), Ribi et al.
patent: 5480582 (1996-01-01), Pope
patent: 5491097 (1996-02-01), Ribi et al.
patent: 5521101 (1996-05-01), Saini et al.
patent: 5571568 (1996-11-01), Ribi et al.
patent: 5618735 (1997-04-01), Saul et al.
patent: 5622872 (1997-04-01), Ribi
Charych et al Mat. Res. Symp. Proc. vol. 292 (1993) pp. 153-161.
Arab et al Glycoconjugate Journal (1996) 13: 159-166.
Pons et al Biochimica et Biophysica Acta 693 (1982) 461-465.
Yuan et al Solid State Communications vol. 80 No. 7 (1991) 493-495.
Charych et al Science vol. 261 (1993) 585-588.
Arisawa et al., "Quantitative characterization of enzymes adsorbed on to Langmuir-Blodgett films and the application to a urea sensor," Thin Solid Films 210:443-445 (1992).
Beswick and Pitt, "Optical Detection of Toxic Gases Using Fluorescent Porphyrin Langmuir-Blodgett Films" J. Colloid Interface Sci. 124:146-155 (1988).
Chance et al., "Thermal effects on the optical properties of single crystals and solution-cast films of urethane substituted polydiacetylenes," J. Chem. Phys. 71:206-211 (1979).
Day et al., Journal of Polymer Science, Letters to the Editor 16:205 (1978); reference unavailable--will be provided at a later date.
Ehlen et al., "Organic Clathrate-Forming Compounds as Highly Selective Sensor Coatings for the Gravimetric Detection of Solvent Vapors," Angew. Chem. Int. Ed. Engl. 32:110-112 (1993).
Furuki and Pu, "Hybrid gas detector of squarylium dye Langmuir-Blodgett film deposited on a quartz oscillator," Thin Solid Films 210: 471-473 [1992].
Kaneko et al., "Absorption properties and structure changes caused by pre-annealing in polydiacetylene Langmuir-Blodgett films," Thin Solid Films 210/211:548-550 (1992).
Mino et al., "Photoreactivity of 10,12-Pentacosadiynoic Acid Monolayers and Color Transitions of the Polymerized Monolayers on an Aqueous Subphase," Langmuir 8:594-598 (1992).
Miyasaka et al., "Amperometric Glucose Sensor with Glucose Oxidase Immobilized on SnO.sub.2 Electrode via a Monolayer of a Photoreactive Nitrophenylazide Derivative," Chem. Lett., p. 627-630 (1990).
Novotny et al., "Tribology of Langmuir-Blodgett Layers," Langmuir 5:485-489 (1989).
Okahata et al., "Preparations of Langmuir-Blodgett Films of Enzyme-Lipid Complexes: A Glucose Sensor Membrane," Thin Solid Films 180:65-72 (1989).
Roberts (ed.) Langmuir-Blodgett Films, Wiley, New York (1966).
Shibata, "Reversible Colour Phase Transitions and Annealing Properties of Langmuir-Blodgett Polydiacetylene Films" Thin Solid Films 179:433-437 (1989).
Spevak et al., "Polymerized Liposomes Containing C-Glycosides of Sialic Acid: Potent Inhibitors of Influenza Virus in Vitro Infectivity," J. Am. Chem. Soc. 115: 1146-1147 [1993].
Swalen et al., "Molecular Monolayers and Films," Langmuir 3:932-950 (1987).
Tieke, "Langmuir-Blodgett Membranes for Separation and Sensing," Adv. Mat. 3:532-541 (1991).
Whitesides et al., "Wet Chemical Approaches to the Characterization of Organic Surfaces: Self-Assembled Monolayers, Wetting, and the Physical-Organic Chemistry of the Solid-Liquid Interface," Langmuir 6:87-96 (1990).
Berman et al., "Total Alignment of Calcite at Acidic Polydiacetylene Films: Cooperativity at the Organic-Inorganic Interface," Science 269:515-518 (1995).
Charych et. al., "A `litmus test` for molecular recognition using artificial membranes," Curr. Biol. 3:113-120 (1996).
Charych et al., "Specific Interaction of Influenza Virus with Organized Assemblies of Polydiacetylenes," Mat. Res. Soc. Symp. Proc. 282:153-161 (1993).
Dagani, "Lipids and Minerals Form Novel Composite Microstructures," Chem. & Eng. News, 19-20 (1993).
Kessel and Granick, "Formation and Characterization of a Highly Ordered and Well-Anchored Alkylsilane Monolyaer on Mica by Self-Assembly," Langmuir 7: 532-538 (1991).
Kingery-Wood et al., "The Agglutination of Erythrocytes by Influenza Virus is Strongly Inhibited by Liposomes Incorporating an Analog of Sialyl Gangliosides," J. Am. Chem. Soc. 114:7303-7305 (1992).
Leung et al. ,"Imaging of polydiacetylene on graphite by scanning tunneling microscopy," J. Appl. Phys. 69(4):2044-2047 (1991).
Lio et al., "Atomic force microscope study of chromatic transitions in polydiacetylene thin films," J. Vac. Sci. Technol. 14(2):1481-1486 (1996).
Miyasaka et al., "Oriented Polypeptide Monolayers by Rapid Spontaneous Condensation of Amphiphilic Amino Acid Esters," The Solid Films 210/211:393-396 (1992).
Ott et al., "Liposomes and influenza viruses as an in vitro model for membrane interactions II. Influence of vesicle size and preparation methods," Eur. J. Pharm. Sci. 6:333-341 (1994).
Perez et al., "Toward Inorganic Monolayers Inserted in a Langmuir-Blodgett Matrix," Thin Solid Films 210/211:410-411 (1992).
Pons et al., "The Optical Activity and Circular Dichroic Spectra of Diacetylenic Phospholipid Polymers," Biochim. Biophys. Acta 693:461-465 (1982).
Rieke et al., "Spatially Resolved Mineral Deposition on Patterned Self-Assembled Monolayers," Langmuir 10:619-622 (1994).
Reichert et al., "Polydiacetylene Liposomes Functionalized with Sialic Acid and Colorimetrically Detect Influenza Virus," J. Am. Chem. Soc. 117:829-830 (1995).
Spevak, "The Presentation of Biological Ligands on the Surface of Polymerized Monolayers and Liposomes," Ph.D. Dissertation, University of California at Berkeley (1993).
Tanev and Pinnavaia, "Biomimetic Templating of Porous Lamellar Silicas by Vesicular Surfactant Assemblies," Science 271:1267-1269 (1996).
Yamanaka et al., "Solid Phase Immobilization of Optically Responsive Liposomes in Sol-gel Materials for Chemical and Biological Sensing," Langmuir 13:5049-5053 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polymeric assay film for direct colorimetric detection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymeric assay film for direct colorimetric detection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymeric assay film for direct colorimetric detection will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-861791

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.