Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-01-31
1998-09-29
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 2372, 536 2433, C12Q 168, C12P 1934, C07H 2104
Patent
active
058144480
ABSTRACT:
This invention provides a method of typing a human papillomavirus in a patient infected by human papillomavirus which comprises: obtaining a sample containing DNA from the human papillomavirus to be typed; amplifying the L1 portion of the human papillomavirus DNA; treating the resulting amplified DNA with a plurality of predetermined restriction enzymes so as to produce restriction fragments; and analyzing the fragments so produces so as to type the human papillomavirus.
REFERENCES:
Bauer H.M., et al., "Genital Human Papillomavirus Infection In Female University Students As Determined By A PCR-Based Method", JAMA, Jan. 23/30, 1991, vol. 265, No. 4, pp. 472-477 (Exhibit 2).
Burmer G.C., et al., "Comparative Analysis of Human Papillomavirus Detection By Polymerase Chain Reaction And Virapap/Viratype Kits", A.J.C.P., Nov. 1990, vol. 94 pp. 554-560 (Exhibit 3).
Grange J.M., "Basic Research And Tuberculosis Elimination Programmes: Recent Developments In Molecular Biology Of Mycobacteria", Bulletin of the International Union Against Tuberculosis and Lung Disease, Jun.-Sep., 1990, vol. 6, No. 2-3, pp. 19-23 (Exhibit 4).
Haliassos A., et al., "Detection of Minority Point Mutations By Modified PCR Technique: A New Approach For A Sensitive Diagnosis Of Tumor-progression Markers", Nucleic Acids Research, 1989, vol. 17, No. 20, pp. 8093-8099 (Exhibit 5).
Hance, A.J., et al., "Detection And Identification Of Mycobacteria By Amplification Of Mycobacterial DNA", Molecular Microbiology, Jul., 1989, vol. 3, No. 7, pp. 843-849, (Exhibit 6).
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Owerbach D., et al., "Direct Analysis of CYP21B Genes in 21-Hydroxylase Deficiency Using Polymerase Chain Reaction Amplification", Molecular Endocrinology, 1990, vol. 4, No. 1, pp. 125-131 (Exhibit 12).
Rodu B., et al., "Simplified PCR-Based Detection and Typing Strategy for Human Papillomaviruses Utilizing a Single Oligonucleotide Primer Set", BioTechniques, 1991, vol. 10, No. 5, pp. 632-636, (Exhibit 13).
Sritharan V., et al., "A Simple Method for Diagnosing M. tuberculosis Infection In Clinical Samples Using PCR", Molecular and Cellular Probes, Apr. 12, 1991, vol. 5, pp. 385-395 (Exhibit 14).
Ting Y., et al., "Detection and Typing of Genital Human Papillomaviruses", PCR Protocols, 1990, Chapter 42, pp. 356-367, (Exhibit 15).
Lungu Octavian
Silverstein Saul J.
Wright, Jr. Thomas C.
Brusca John S.
Ketter James
The Trustees of Columbia University in the City of New York
White John P.
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