Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1995-06-06
1997-07-22
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 436601, 436 63, 514 2, 514 44, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 935 77, 935 78, C12Q 168
Patent
active
056502680
ABSTRACT:
The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose infection has become resistant to a particular antiretroviral drug regimen.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5008182 (1991-04-01), Sninsky et al.
Chomczynski et al., 1987, "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction" Anal. Biochem. 162:156-159.
Ehrnst et al., 1988, "Efficient Isolation of HIV From Plasma During Different Stages of HIV Infection" J. Med. Virol. 26:23-32.
Hewlett et al., 1988, "Detection in Plasma of HIV-1 Specific DNA and RNA by Polymerase Chain Reaction Before and After Seroconversion" J. Clin. Immunoassay 11:161-164.
Coombs et al., 1989, "Plasma Viremia in Human Immunodeficiency Virus Infection" N. Engl. J. Med. 321:1626-31.
Ho et al., 1989, "Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons" N. Engl. J. Med. 321:1621-1625.
Larder et al., 1989, "HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy" Science 243:1731-1734.
Larder et al., 1989, "Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)" Science 246:1155-1158.
Meyerhans et al., 1989, "Temporal Fluctuations in HIV Quasispecies In Vivo Are Not Reflected by Sequential HIV Isolations" Cell 58:901-910.
Rooke et al., 1989, "Isolation of Drug-Resistant Variants of HIV-1 From Patients on Long-Term Zidovudine Therapy" AIDS 3:411-415.
Tersmette et al., 1989, "Association Between Biological Properties of Human Immunodeficiency Virus Variants and Risk for AIDS and AIDS Mortality" Lancet 1:983-985.
Aoki et al., 1990, "Quantitative Analysis of HIV-1 Proviral DNA in Peripheral Blood Mononuclear Cells from Patients with AIDS or ARC: Decrease of Proviral DNA Content Following Treatment with 2', 3'-Dideoxyinosine (ddl)" AIDS Res. Hum. Retroviruses 6:1331-1339.
Boucher et al., 1990, "Zidovudine Sensitivity of Human Immunodeficiency Viruses From High-Risk, Symptom-Free Individuals During Therapy" Lancet 336:585-590.
Coyle et al., 1990, "Detection of Human Immunodeficiency Virus in Plasma by RNA Directed Polymerase Chain Reaction in a Cohort of Hemophiliacs" Clin. Res. 38:778a (Abstr.).
Fischl et al., 1990, "A Randomized Controlled Trial of a Reduced Daily Dose of Zidovudine in Patients with the Acquired Immunodeficiency Syndrome" N. Engl. J. Med. 323:1009-1014.
Karpas et al., 1990, "Polymerase Chain Reaction Evidence for Human Immunodeficiency Virus 1 Neutralization by Passive Immunization in Patients With AIDS and AIDS-related Complex" Proc. Natl. Acad. Sci. USA 87:7613-7617.
Kawasaki, 1990, "In PCR Protocals: A Guide to Methods and Applications" pp. 21-27, M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White, eds. Academic Press, Berkeley, California.
Kellog et al., 1990, "In PCR Protocols: A Guide to Methods and Applications" pp. 337-347, M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White, eds. Academic Press, Berkeley, California.
Land etal ., 1990, "Decreased In Vitro Susceptibility to Zidovudine of HIV Isolates Obtained from Patients with AIDS" J. Infect. Dis. 161:326-329.
Levenson et al, 1990, "In PCR Protocols: A Guide to Methods and Applications" pp. 99-112, M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White, eds. Academic Press, Berkeley, California.
Richman et al., 1990, "Effect of Stage of Disease and Drug Dose on Zidovudine Susceptibilities of Isolates of Human Immunodeficiency Virus" J. AIDS 3:743-746.
Volberding et al., 1990, "Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection" N. Engl. J. Med. 322:941-949.
Bagnarelli et al., 1991, "Detection of Human Immunodeficiency Virus Type 1 Genomic RNA in Plasma Samples by Reverse-Transcription Polymerase Chain Reaction" J. Med. Virol. 34:89-95.
Daar et al., 1991, "Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection" N. Engl. J. Med. 324:961-964.
Escaich et al., 1991, "Plasma Viraemia as a Marker of Viral Replication in HIV-Infected Individuals" AIDS 5:1189-1193.
Holodniy et al., 1991, "Inhibition of Human Immunodeficiency Virus Gene Amplification by Heparin" J. Clin. Microbiol. 29:676:679.
Holodniy et al., 1991, "Detection and Quantification of Human Immunodeficiency Virus RNA in Patient Serum by Use of the Polymerase Chain Reaction" J. Infect. Dis. 163:862-866.
Holodniy et al., 1991, "Reduction in Plasma Human Immunodeficiency Virus Ribonucleic Acid after Dideoxynucleoside Therapy as Determined by the Polymerase Chain Reaction" J. Clin. Invest. 88:1755-1759.
Japour et al., 1991, "Detection of Human Immunodeficiency Virus Type 1 Clinical Isolates With Reduced Sensitivity to Zidovudine and Dideoxyinosine by RNA-RNA Hybridization" Proc. Natl. Acad. Sci. USA 88:3092-3096.
Larder et al., 1991, "Zidovudine Resistance Predicted by Direct Detection of Mutations in DNA From HIV-Infected Lymphocytes" AIDS 5:137-144.
McElrath et al., 1991, "Latent HIV-1 Infection in Enriched Populations of Blood Monocytes and T Cells from Seropositive Patients" J. Clin. Invest. 87:27-30.
Ottman et al., 1991, "The Polymerase Chain Reaction for the Detection of HIV-1 Genomic RNA in Plasma From Infected Individuals" J. Virol Methods 31:273-284.
Richman et al., 1991, "Detection of Mutations Associated with Zidovudine Resistance in Human Immunodeficiency Virus by Use of the Polymerase Chain Reaction" J. Infect. Dis. 164:1075-1081.
Semple et al., 1991, "Direct Measurement of Viraemia in Patients Infected With HIV-1 and Its Relationship to Disease Progression and Zidovudine Therapy" J. Virol. Methods 35:38-45.
St Clair et al., 1991 "Resistance to ddl and Sensitivity to AZT Inducted by a Mutation in HIV-1 Reverse Transcriptase" Science 253:1557-1559.
Boucher et al., 1992, "Ordered Appearance of Zidovudine Resistance Mutations During Treatment of 18 Human Immunodeficiency Virus-Positive Subjects" J. Infect. Dis. 165:105-110.
Bush et al., 1992, "Detection of Human Immunodeficiency Virus Type 1 RNA in Plasma Samples from High-Risk Pediatric Patients by Using the Self-Sustained Sequence Replication Reaction" J. Clin Microbiology 30(2):281-286.
Henrard et al., 1992, "A Sensitive Viral Capture Assay for Detection of Plasma viremia in HIV-Infected Individuals" AIDS Res. Hum. Retroviruses 8:47-52.
Kellam et al., 1992, "Fifth Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Contributes to the Development of High-Level Resistance to Zidovudine" Proc. Natl. Acad. Sci. USA 89:1934-1938.
Kusumi et al., 1992, "Human Immunodeficiency Virus Type 1 Envelope Gene Structure and Diversity In Vivo and After Cocultivation In Vitro" J. Virol. Methods 66:875-885.
Tudor-Williams et al., 1992, "HIV-1 Sensitivity to Zidovudine and Clinical Outcome in Children" Lancet 339:15-19.
Yerly et al., 1992, "Quantitaion of Human Immunodeficiency Virus Provirus and Circulating Virus: Relationship with Immunologic Parameters" J. Infect. Dis. 166:269-76.
Kozal Michael J.
Merigan Thomas C.
Coruzzi Laura A.
Leland Stanford Junior University
Marschel Ardin H.
Zitomer Stephanie W.
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