Polymer reversal on solid surfaces

Details Polymer reversal on solid surfaces Polymer reversal on solid surfaces

1994-11-28

1996-08-27

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

525 5411, 536 253, 536126, C07H 100, C07K 104, C08B 3700, C08F28300

Patent

active

055502156

ABSTRACT:
A method for cyclization and reversal of the polarity of polymers on a substrate. The method provides for the formation of a polymer on a substrate (2) with a tether molecule (4). Through unmasking of a protective group (PG.sub.2) a cyclic polymer (6) is formed. Through cleavage of an appropriate bond, a polarity reversed polymer (8) is formed. The method finds particular application in the formation of, for example, peptides and oligonucleotides.

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