Polymer, production and use thereof

Details Polymer, production and use thereof Polymer, production and use thereof

1987-11-06

1989-07-18

Nielsen, Earl

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424426, 424455, 514937, 528354, 528361, 264 46, A61K 952

Patent

active

048492280

ABSTRACT:
The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.
The thus-obtained high molecular polymer has good aging stability and can be used advantageously as an exipient for pharmaceutical preparations.

REFERENCES:
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patent: 3565869 (1971-02-01), DeProspero
patent: 3839297 (1974-10-01), Wasserman et al.
patent: 3890283 (1975-06-01), Casey et al.
patent: 3912692 (1975-10-01), Casey et al.
patent: 4249531 (1981-02-01), Heller et al.
patent: 4273920 (1981-06-01), Nevin
patent: 4479911 (1984-10-01), Fong
patent: 4605730 (1986-08-01), Shalaby et al.
patent: 4652441 (1987-03-01), Okada et al.
Colin G. Pitt, et al, "Sustanined Drug Delivery Systems", I. The Permeablity of Poly(eta-Caprolactone), Poly (DL-Lactic Acid), and Their Copolymers, Journal of Biomedical Materials Research, vol. 13, pp. 498-507 (1979).

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