Polymer NEMS for cell physiology and microfabricated cell...

Measuring and testing – Dynamometers – Responsive to force

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S287100, C977S724000, C977S956000, C977S958000

Reexamination Certificate

active

07966898

ABSTRACT:
A microfluidic embedded nanoelectromechanical system (NEMs) force sensor provides an electrical readout. The force sensor contains a deformable member that is integrated with a strain sensor. The strain sensor converts a deformation of the deformable member into an electrical signal. A microfluidic channel encapsulates the force sensor, controls a fluidic environment around the force sensor, and improves the read out. In addition, a microfluidic embedded vacuum insulated biocalorimeter is provided. A calorimeter chamber contains a parylene membrane. Both sides of the chamber are under vacuum during measurement of a sample. A microfluidic cannel (built from parylene) is used to deliver a sample to the chamber. A thermopile, used as a thermometer is located between two layers of parylene.

REFERENCES:
patent: 4711820 (1987-12-01), Arkles et al.
patent: 6408878 (2002-06-01), Unger et al.
patent: 6540895 (2003-04-01), Spence et al.
patent: 6575020 (2003-06-01), de Charmoy et al.
patent: 6793753 (2004-09-01), Unger et al.
patent: 6899137 (2005-05-01), Unger et al.
patent: 6929030 (2005-08-01), Unger et al.
patent: 7040338 (2006-05-01), Unger et al.
patent: 7144616 (2006-12-01), Unger et al.
patent: 7169314 (2007-01-01), Unger et al.
patent: 7214298 (2007-05-01), Spence et al.
patent: 7216671 (2007-05-01), Unger et al.
patent: 2004/0211243 (2004-10-01), Porter et al.
patent: 2010/0000292 (2010-01-01), Karabacak et al.
patent: 2010/0233792 (2010-09-01), Begley et al.
patent: 94/28372 (1994-12-01), None
patent: 02/12443 (2002-02-01), None
patent: 03/022731 (2003-03-01), None
patent: 03/095616 (2003-11-01), None
patent: 2005/119233 (2005-12-01), None
Snow et al. “Static deflection measurements of cantilever arrays reveal polymer film expansion and contraction”, Journal of Colliod and Interface Science, vol. 316, pp. 687-693. Aug. 30, 2007.
Roukes, M. Nanoelectromechanical systems face the future. Phys. World 14, 25-31 (Feb. 2001).
Cleland, A. N. & Roukes, M. L. A nanometre-scale mechanical electrometer. Nature 392, 160-162 (1998).
Rugar, D. et al. Single spin detection by magnetic resonance force microscopy. Nature 430, 329-332 (2004).
Yang, Y. T. et al. Zeptogram-scale nanomechanical mass sensing. Nano Lett. 6 (4), 583-586 (2006).
Mamin, H. J. & Rugar, D. Sub-attonewton force detection at millikelvin temperatures. Appl. Phys. Lett. 79 (20), 3358-3360 (2001).
Naik, A. et al. Cooling a nanomechanical resonator with quantum back-action. Nature 443, 193-196 (2006).
Schwab, K. C. & Roukes, M. L. Putting mechanics into quantum mechanics. Phys. Today 58, 36-42 (Jul. 2005).
Tortonese, M., Barrett, R. C. & Quate, C. F. Atomic resolution with an atomic force microscope using piezoresistive detection. Appl. Phys. Lett. 62 (8), 834-836 (1993).
Landau, L. D. and Lifshitz E. M.Theory of Elasticity(1959), pp. viii, 1-14, 64-81.
Thaysen, J. Yalcinkaya, AD, Vettiger, P., and Menon, A. Polymer-based stress sensor with integrated readout. J. Phys. D: Appl. Phys. 35, 2698-2703 (2002).
Mo Li, H.X. Tang, and M.L. Roukes, Ultra-sensitive NEMS-based cantilevers for sensing, scanned probe and very high-frequency applications, Nature Nanotechnology, vol. 2, Feb. 2007, 114-120 (Jan. 28, 2007).
D. Martin Knotter and T.J.J. (Dee) Denteneer, Etching Mechanism of Silicon Nitride in HF-Based Solutions, Journal of the Electrochemical Society 148 (3) F43-F46 (2001).
John L. Tan, Wendy Liu, Celeste M. Nelson, Srivatsan Raghavan, and Christopher S. Chen, Simple Approach to Micropattern Cells on Common Culture Substrates by Tuning Substrate Wettability, Tissue Engineering, vol. 10, No. 5/6, 865-872 (2004).
Milan Mrksich, Chrisopher S. Chen, Younan Xia, Laura E. Dike, Donald E. Ingber, and George M. Whitesides, Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold, Proc. Natl. Acad. Sci. USA vol. 93, pp. 10775-10778 (Oct. 1996).
T.G.I. Ling, M. Beck, R. Bunk, E. Forsen, J.O. Tegenfeldt, A.A. Zakharov, L. Montelius, Fabrication and chacterization of a molecular adhesive layer for micro- and nanofabricated electrochemical electrodes, Microelectronic Engineering 67-68 (2003) 887-892.
Chun-Min Lo, Hong-Bei Wang, Micah Dembo, and Yu-li Wang, Cell Movement is Guided by the Rigidity of the Substrate, Biophyscial Journal, vol. 79, pp. 144-152 (Jul. 2000).
John L. Tan, Joe Tien, Dana M. Pirone, Darren S. Gray, Kiran Bhadriraju, and Christopher S. Chen, Cells lying on a bid of microneedles: An approach to isolate mechanical force, Proceedings of the National Academy of Sciences, vol. 100, No. 4, pp. 1484-1489 (Feb. 18, 2003).
Arkles, B., Tailoring Surfaces with Silanes, CHEMTECH, 7(12), 766-778 (1977).
van Ruitenbeek, J. M., Alvarez, A., Pineyro, I., Grahman, C., Joyez, P., Devoret, M. H., Esteve, D., and Urbina, C. Adjustable nanofabricated atomic sized contacts.Review of Scientific Instruments, 67 (1), 108-111 (1996).
Johannessen, E A, Weaver, J M, Cobbold, P H, Cooper, J M. Heat conduction nanocalorimeter for pl-scale single cell measurement.Appl. Phys. Lett., 80 (11), 2029-2031 (2002).
Zhang, Y, and Tadigadapa, S. Calorimetric biosensors with integrated microfluidics channels.Biosensors and Bioelectronics, 19, 1733-1743 (2004).
Baier, V., Highly sensitive thermopile heat power sensor for micro-fluid calorimetry of biochemical processes, Sensors and Actuators A 123-124 (2005) 354-359.
Zhang, Y. and Tadigadapa, S., Thermal characterization of liquids and polymer thin films using a microcalorimeter, Applied Physics Letters 86, 034101 (2005).
Gelest Data Sheet, Applying a silane coupling agent.
Partial International Search Report for International Application No. PCT/US2007/016975 filed on Jul. 30, 2007.
International Search Report dated Mar. 12, 2008, International application No. PCT/US2007/016975, International filing date Jul. 30, 2007.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polymer NEMS for cell physiology and microfabricated cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymer NEMS for cell physiology and microfabricated cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymer NEMS for cell physiology and microfabricated cell... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2661592

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.