Polymer-modified peptide drugs having enhanced biological and ph

Details Polymer-modified peptide drugs having enhanced biological and ph Polymer-modified peptide drugs having enhanced biological and ph

1990-04-24

1992-02-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

530402, 530816, 514 2, A61K 3174, C07K 300, C07G 702

Patent

active

050911767

ABSTRACT:
Biocompatible polymers derived from isocyanate-capped high molecular weight triols and higher polyols are covalently linked to drugs. These polymer-modified drugs have one or more of the following advantages over the unmodified drug: reduction of immunogenicity of the drug, increased circulating half-life of the drug due to longer residence time in circulation, ability to administer multiple drugs together, and enhanced potency of the drug.

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