Polymer microspheres/nanospheres and encapsulating...

Plastic and nonmetallic article shaping or treating: processes – Formation of solid particulate material directly from molten... – By extrusion spraying or gravity fall through orifice

Reexamination Certificate

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C264S005000, C264S012000, C425S006000

Reexamination Certificate

active

07147806

ABSTRACT:
This invention is for an improved process to formulate polymeric microspheres
anospheres and encapsulate therapeutic proteins and other useful substances. Non-toxic supercritical or near-critical fluids with/without polar cosolvents are utilized to solubilize biodegradable polymers and form uniform polymer microspheres and nanospheres to encapsulate proteins with controlled-release characteristics.

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Mathiowitz, E., Jacob, J.S., Jong, Y.S., Carino, G.P., Chickering, D.E., Chaturvadi, P., Santos, C.A., Vijaaraghavan, K., Montgomery, S., Bassett, M. and Morrell, C. “Biologically Erodable Microspheres as Potential Oral Drug Delivery Systems”,Nature,386:410-414 (1997).

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