Polymer micelle as monolayer or layer-laminated surface

Details Polymer micelle as monolayer or layer-laminated surface Polymer micelle as monolayer or layer-laminated surface

2006-05-02

2006-05-02

Azpuru, Carlos A. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S423000, C424S428000, C424S450000, C623S006110

Reexamination Certificate

active

07037517

ABSTRACT:
The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.

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patent: WO 99/26665 (1999-06-01), None
Emoto, K. et al, “Coating of Surfaces with Stabilized Reactive Micelles from (Poly(ethylene glycol)- Poly(DL-lactic acid) Block Copolymer,” Langmuir, 15:5212-5218 (1999).
Emoto, K. et al., “Coating of Surfaces with Stabilized Reactive Micelles from Poly(ethylene glycol)- Poly(DL-lactic acid) Block Copolymer,”Langmuir, 15: 5212-5218 (1999).
Emoto, K. et al., “A Core-Shell Structured Hydrogel Thin Layer on Surfaces by Lamination of a Poly9ethylene glycol)-b-poly(D,L-lactide) Micelle and Polyallylamine”, Langmuir, 16: 5738-5742 (2000).
Emoto, et al. “Functionality of Polymeric Micelle Hydrogels with Organized Three-Dimensional Architecture on Surfaces”,J. Am. Chem. Soc.,122: 2653-2654 (2000).

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