Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1997-10-28
1999-11-02
Short, Patricia A.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
522 79, 522111, 526276, 526277, 525100, 525148, 525154, 525175, 525183, 525189, 525197, 525209, C08L 7504, C08J 328
Patent
active
059772573
DESCRIPTION:
BRIEF SUMMARY
FIELD OF ART
The present invention relates to a high molecular material which is a polymer mixture material useful as a medical material, a cosmetic material, a coating material and the like, and a liquid high molecular composition as a starting material thereof, as well as a medical material which is a polymer mixture having both superior biocompatibility and dynamic strength, and a high molecular composition for the medical material as a starting material thereof.
BACKGROUND OF ART
A polymer containing a phosphorylcholine group has a structure similar to that of a phospholipid constituting a cell membrane, and therefore has high biocompatibility, to exhibit superior properties as a medical high molecular material, such as non-activating ability of a complement including blood coagulation factor, lack of biomaterial (including protein and cells) absorbing property, antithrombus property, moisture holding property, and lipid bilayer stabilizing ability (Kazuhiko Ishihara, et.al., Journal of Biomedical Materials Research, 24(1990) 1069-1077, Kazuhiko Ishihara, et.al., Journal of Biomedical Materials Research, 25(1991) 1397-1407).
Development of bio-related materials utilizing these properties has actively been performed. For example, it is described in Japanese Laid-open Patent Application No.91-39309 that a copolymer of 2-methacryloyloxyethylphosphorylcholine and an ester of methacrylic acid is a superior biocompatible material. It is described in WO93/01221 that, when a polymer containing a phosphorylcholine group is utilized as a coating material, the coated article can be used as a material having a biocompatible surface for various bio-related purposes. It is disclosed in WO93/16117 that a water-soluble cellulose derivative produced by graft polymerization of a water-soluble cellulose with 2-methacryloyloxyethylphosphorylcholine has both biocompatibility and affinity with cellulose, and can be used as biocompatible material for, e.g., hemocatharsis. It is disclosed in Japanese Laid-open Patent Application No.84-43342 that a high molecular composition of a moisture sensor material consisting of a polymer having a phosphorylcholine group and a thin film material which is a water-soluble polymer is useful as a moisture sensor material. It is disclosed in Japanese Laid-open PCT application No. 95-504459 that a high molecular composition of a polymer having a phosphorylcholine group and a polymer having desirable mechanical and/or physical properties is suitable for a biomedical material. Various monomers, homopolymers, and copolymers having a phosphorylcholine group, and methods for producing the same are previously known as described in, e.g., Japanese Laid-open Patent Application Nos. 79-63025, 83-154591, 88-222183, 93-107511 and 94-41157, and WO093/01221.
Although a polymer or copolymer having the phosphorylcholine group has significant biocompatibility, mechanical properties such as dynamic strength and durability are not always sufficient, in terms of a medical material. Thus, various studies have been made regarding copolymerizable monomers to be copolymerized with the monomer having a phosphorylcholine group. An attempt to improve dynamic strength and durability by mixing a hydrophobic polymer having such properties has also been made. However, in the case of the polymer having a phosphorylcholine group, which is a functional group exhibiting a uniquely significant water-solubility, sufficiently good result has not yet been obtained unlike the case of conventionally performed mixing of hydrophobic polymers with another hydrophobic polymer.
Alternatively, it is known that a segmented polyurethane is superior in dynamic properties, and has better blood compatibility than other materials (Japanese Laid-open Patent Application No.82-139352, European Patent Specification No.68385, U.S. Pat. No. 4,379,904, WO83/00695). Such segmented polyurethanes are widely used as medical materials such as blood circuits, artificial hearts, various catheters, and medical sensors ("Artificial Organs" Ed. Tetsuzo Agis
Ishihara Kazuhiko
Matsuyama Kazuo
Nakabayashi Nobuo
Shiino Daijiro
Waki Kazunori
Japan Science and Technology Corporation
NOF Corporation
Short Patricia A.
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