Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2005-07-11
2009-08-18
Nashed, Nashaat T. (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S101000
Reexamination Certificate
active
07575904
ABSTRACT:
The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate synthase fromPasteurella multocida. The present invention also relates to coatings for biomaterials wherein the coatings provide protective properties to the biomaterial and/or act as a bioadhesive. Such coatings could be applied to electrical devices, sensors, catheters and any device which may be contemplated for use within a mammal. The present invention further relates to drug delivery matrices which are biocompatible and may comprise combinations of a biomaterial or a bioadhesive and a medicament or a medicament-containing liposome. The biomaterial and/or bioadhesive is a hyaluronic acid polymer produced by a hyaluronate synthase fromPasteurella multocida. The present invention also relates to the creation of chimeric molecules containing hyaluronic acid or hyaluronic acid-like chains attached to various compounds and especially carbohydrates or hydroxyl containing substances. The present invention also relates to a chondroitan synthase fromPasteurella multocidawhich is capable of producing polysaccharide polymers on an acceptor or primer molecule.
REFERENCES:
patent: 4511478 (1985-04-01), Nowinski et al.
patent: 4615697 (1986-10-01), Robinson
patent: 4822867 (1989-04-01), Erhan
patent: 4983392 (1991-01-01), Robinson
patent: 5015577 (1991-05-01), Weigel et al.
patent: 5171689 (1992-12-01), Kawaguri et al.
patent: 5217743 (1993-06-01), Farah
patent: 5337747 (1994-08-01), Neftel
patent: 5472704 (1995-12-01), Santus et al.
patent: 5473034 (1995-12-01), Yasui et al.
patent: 5607694 (1997-03-01), Marx
patent: 5610241 (1997-03-01), Lee et al.
patent: 5631019 (1997-05-01), Marx
patent: 5651982 (1997-07-01), Marx
patent: 5711959 (1998-01-01), Kohler et al.
patent: 5837747 (1998-11-01), Soon-Shiong et al.
patent: 5885609 (1999-03-01), Amiji
patent: 5928687 (1999-07-01), Rosenblatt et al.
patent: 5945457 (1999-08-01), Plate et al.
patent: 5962136 (1999-10-01), Dewez et al.
patent: 6284493 (2001-09-01), Roth
patent: 6444447 (2002-09-01), DeAngelis
patent: WO95/24497 (1995-09-01), None
patent: WO97/20061 (1997-06-01), None
patent: WO99/51265 (1999-10-01), None
Chica et al. (Curr Opin Biotechnol. Aug. 2005; 16(4):378-84.
Witkowski et al. (Biochemistry. Sep. 7, 1999; 38(36): 11643-50.
Seffernick et al. (J Bacteriol. Apr. 2001; 183 (8): 2405-10.
Biomimetic Transport and Rational Drug Delivery, Ranney, et al., Biochemical Pharmacology, vol. 59, pp. 105-114, 2000.
Glycosidases and Glycosyl Transferases in Glycoside and Oligosaccharide Synthesis, Crout, et al., Current Opinion in Chemical Biology, pp. 2:98-111, 1998.
Enzymological Characterization of the Pasteurella Multocida Hyaluronic Acid Synthase, DeAngelis, Biochemistry, vol. 35, No. 30, pp. 9768-9771, 1996.
Enzymatic Reconstruction of a Hybrid Glycosaminoglycan Containing 6-Sulfated, 4-Sulfated, and Unsulfated N-Acetylgalactosamine, Takagaki, et al., Biochemical and Biophysical Research Communications 258, pp. 741-744, 1999.
Enzymic Reconstruction of Glycosaminoglycan Oligosaccharide Chains Using the Transglycosylation Reaction of Bovine Testicular Hyaluronidase, Saitoh, et al., The American Society for Biochemistry and Molecular Biology, Inc., vol. 270, No. 8, pp. 3741-3747, Feb. 24, 1995.
Chimeric Glycosaminoglycan Oligosaccharides Synthesized by Enzymatic Reconstruction and Their Use in Substrate Specificity Determination of Streptococcus Hyaluronidase, Takagaki, et al., J. Biochem. vol. 127, pp. 695-702, 2000.
Identification and Molecular Cloning of a Unique Hyaluronan Synthase from Pasteurella Multocida, DeAngelis, et al., J. Biol. Chem., vol. 273, Issue 14, pp. 8454-8458, 1998.
Hyaluronan Synthases, Weigel et al., The Journal of Biologicaly Chemistry, vol. 272, No. 22, Issue of May 30, pp. 13997-14000, 1997.
The capsule biosynthetic locus of Pasteurella multocida A:1, Chung, et al., FEMS Microbiology Letters 166, p. 289-296, 1998.
Molecular Cloning, Expression, and Characterization of the Authentic Hyaluronan Synthase from Group CStreptococcus equisimilis*, Kumari et al., J. Biol. Sci., 272 (51):32539-32546, 1997.
Enzymological Characterization of Recombinant Xenopus DG42, A Vertebrate Hyaluronan Synthase*, Pummill et al., J. Biol. Sci., 273 (9):4976-4981, 1998.
Dunlap Codding P.C.
Meah Md. Younus
Nashed Nashaat T.
The Board of Regents of the University of Oklahoma
LandOfFree
Polymer grafting by polysaccharide synthases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polymer grafting by polysaccharide synthases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymer grafting by polysaccharide synthases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4056631