Polymer gel for medical use

Details Polymer gel for medical use Polymer gel for medical use

1997-09-17

1999-11-09

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

424 7808, A61K 31765, A61K 31785

Patent

active

059808837

ABSTRACT:
Provided is a medical material useful for wound dressings or a drug delivery system, which material is safe and has high healing effects, more specifically, which is free from cytotoxicity or other side effects caused by a drug and permits the selective healing of the diseased site in a small dosage without damaging the sites other than the diseased site.
The medical material so provided is a polymer gel having a sequence represented by the formula: A-Sp1-E-Sp2-G wherein A represents a water-swelling polymer gel, Sp1 represents the first spacer, E represents a cleavable group with the main chain to be cleaved via an enzymatic reaction, Sp2 represents the second spacer and G represents a drug. When the polymer gel is used, the cleavable group (E) is cleaved according to an amount of an enzyme existing at the diseased site to release the drug in accordance with the amount of the enzyme.

REFERENCES:
patent: 5599702 (1997-02-01), Sauber
patent: 5658592 (1997-08-01), Tanihara et al.
patent: 5679371 (1997-10-01), Tanihara et al.
patent: 5770229 (1998-06-01), Tanihara et al.

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