Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1997-06-17
1999-10-05
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424400, A61K 908, A61K 4734, A61K 4722
Patent
active
059620064
ABSTRACT:
The invention is directed to a polymer formulation in which a pharmaceutically acceptable, biocompatible, biodegradable and/or bioerodible, water-coagulable thermoplastic polymer or copolymer which is substantially insoluble in an aqueous medium is dissolved in .epsilon.-caprolactone, a pharmaceutically-acceptable, moderately water-soluble organic solvent. When brought in contact with an aqueous environment, such as body or tissue fluids, the .epsilon.-caprolactone slowly dissipates into the aqueous fluid. As the .epsilon.-caprolactone dissipates, the water-insoluble thermoplastic polymer coagulates to form a flexible matrix. Preferably, the thermoplastic polymer is a copolymer of caprolactone or methylene carbonate and lactide or glycolide monomers. More preferably, the thermoplastic polymer is poly(DL-lactide-co-caprolactone). The polymer formulation may also contain a biologically active agent and/or a rate modifying agents to control the rate of release of the biologically active agent. The invention is also directed to a method of making the pliable matrix and the pliable matrix itself.
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Dunn Richard L.
Southard Jeffrey L.
Atrix Laboratories, Inc.
Webman Edward J.
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