Polymer-drug conjugate and a method of producing it

Details Polymer-drug conjugate and a method of producing it Polymer-drug conjugate and a method of producing it

1991-03-28

1992-07-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

514 34, 514 42, 514 50, 514261, 514370, 514396, 514729, 514925, A61K 3174, A61K 3152, A61K 31557

Patent

active

051301261

ABSTRACT:
The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.

REFERENCES:
Abuchowski et al. (1984), Cancer Biochem. Biophys., vol. 7, pp. 175-186.
Katre et al. (1987), Proc. Natl. Acad. Sci. USA, vol. 84, pp. 1487-1491.
Chemical Abstracts 96(8): 57661c, (1981).
Chemical Abstracts 108(26: 226780q, (1987).
Chemical Abstracts 111(24): 219277q, (1989).

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