Polymer containing calcium sulfate particles for bone...

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Processes of preparing a desired or intentional composition...

Reexamination Certificate

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C523S205000

Reexamination Certificate

active

07488761

ABSTRACT:
An implant composition having controlled resorption rate in vivo for stimulating bone growth, a method of making the implant composition, and a kit of implant materials are disclosed. The implant composition includes a calcium sulfate compound, polymer containing particles, and a setting agent. The polymer is one or more poly(desaminotyrosyl-tyrosine alkyl ester carbonate). Upon setting, the calcium sulfate compound forms a matrix and the polymer containing particles settled within the matrix. The resorption rate of the implant composition in vivo can be controlled of between eight and twenty-four weeks, which substantially matches the rate of bone growth. The implant composition of the present invention can be used for the repair, augmentation, and other treatment of bone.

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Tangpasuthadol et al. Hydrolytic degradation of Tyrosine-derived polycarbonates, a class of new biomaterials. Biomaterials vol. 21, Issue 23, Dec. 1, 2000.
Bourke, et al. Polymers derived from the amino acid tyrosine: polycarbonates, polyarylates and copolymers with poly(ethylene glycol). Advanced Drug Delivery Reviews, vol. 55, Issue 4, Apr. 25, 2003.
Choueka, et al. Canine bone response to tyrosine-derived polycarbonates and poly (L-lactic acid). 1:J Biomed Mater Res. May 1996; 31 (1):35-41.
James et al. Small changes in polymer chemistry have a large effect on the bone-implant interface: Evaluation of a series of degradable tyrosine-derived polycarbonates in bone defects. 1: Biomaterials. 1999; Dec;20(23-24) 2203-12.

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