Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2004-03-16
2008-11-04
Bunner, Bridget E (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C530S395000, C530S402000, C424S085400, C514S012200, C930S142000
Reexamination Certificate
active
07446173
ABSTRACT:
An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
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Brickelmaier Margot
Hochman Paula
Pepinsky Blake
Runkel Laura
Whitty Adrian
Biogen Idec MA Inc.
Bunner Bridget E
Hamud Fozia M
Miller Canfield Paddock and Stone
O'Brien Jonathan P.
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