Polymer conjugates of interferon beta-1a and uses

Details Polymer conjugates of interferon beta-1a and uses Polymer conjugates of interferon beta-1a and uses

2005-11-08

2005-11-08

Kunz, Gary (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

C530S395000, C530S402000, C514S012200, C424S085600, C930S142000

Reexamination Certificate

active

06962978

ABSTRACT:
An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.

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