Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-04-30
2000-02-29
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514772, 514773, 514 21, A01N 3718
Patent
active
060309415
ABSTRACT:
Polymeric compositions effective for delivering compounds in living organisms are described. The compositions include polypeptides which exhibit solubility in both hydrophilic and lipophilic environments by undergoing a reversible pH-dependent transition from a low-pH, lipophilic form to a high-pH, hydrophilic form.
REFERENCES:
patent: 4356166 (1982-10-01), Peterson et al.
patent: 5087616 (1992-02-01), Myers et al.
patent: 5593974 (1997-01-01), Rosenberg et al.
patent: 5626862 (1997-05-01), Brem et al.
International Search Report.
Adams, N.W., et al., "Controlled Release Polyamino Acid-drug Conjugates for Subcutaneous Injection," 198.sup.th American Chemical Society National Meeting, Miami Beach, Florida, USA, Sep. 10-15, 1989. In: Abstr Pap Am Chem Soc, vol. 198, Abstr No. 113.
Anderson, R.G.W., et al., "Potocytosis: Sequestration and Transport of Small Molecules by Caveolae, " Science 255:410-411 (1992).
Bennett, D.B. et al., "Drug-Coupled Poly(Amino Acids) As Polymeric Prodrugs," J. of Bioactive and Compatible Polymers 3:44-52 (1988).
Fabre, I., et al., "Polyglutamylation, an Important Element in Methoxetrate Cytotoxicity and Selectivity in Tumor Versus Murine Granulocytic Progenitor Cells in Vitro," Cancer Res. 44:3190-3195 (1984).
Kato, Y., et al., "Antitumor Activity of 1-.beta.-D-Arabinofuranosylcytosine Conjugated with Polyglutamic Acid and Its Derivative," Cancer Res. 44:25-30 (1984).
Kim, C-K, et al, "Effects of molecular Weights on the Physio-Pharmaceutical Properties of Poly-L-Glutamic Acid Cytarabine Conjugates," Biol. Abstr. vol.BA88 Abstr. No. 110606.
Li, C., et al., "Development of a Highly Efficacious Water-Soluble Polymer-Taxol Conjugate," Proc. of the Eigthy-Eighth Annual Meeting of the American Association for Cancer Res., San Diego, California, USA, Apr. 12-16, 1997, #1731 pp. 258.
Malley, A., and L. Deppe, "Anti-Timothy IgE Formation: Supression with Antigen D-dGI Conjugates," Int. Archs Allergy appl. Immun. 63:113-120 (1980).
McCormick-Thompson, L. and R. Duncan, "Poly(amino acid) Copolymers as a PotentialSoluble Drug Delivery System. 1. Pinocytic Uptake and Lysosomal Degradation Measured In Vitro," J. of Bioacitve and Compatible Polymers 4:242-250 (1989).
McCormick-Thompson, L., et al., "Poly(amino acid) Copolymers as a Potential Soluble Drug Delivery System. 2. Body Distribution and Preliminary Biocompatibility Testing In Vitro and in Vivo," J. of Bioactive and Compatible Polymers 4:252-268 (1989).
Morimoto, Y., et al., "Antitumor Agent Poly (Amino Acid) Conjugates as a Drug Carrier in Cancer Chemotherapy," J. Pharm. Dyn. 7:688-698 (1984).
Rosenablatt, D. and V.M. Whitehead, "Methotrexate Polyglutamates in Cultured Human Cells," Adv. Exp. Med. Biol. 163 :275-285 (1983).
Rosenblatt, D.S., et al., "Differential Effects of Folinic Acid and Glycine, Adenosine, and Thymidine as Rescue Agents in Methotrexate-Treated Human Cells in Relation to the Accumulation of Methotrexate Polyglutamates," Molecular Pharmacology 21:718-722 (1982).
Tannock, I., and D. Rotin, "Acids pH in Tumors and Its Potential for Therapeutic Exploitation," Cancer Res. 49:4373-4384 (1989).
Vaupel, P. et al., "Blood Flow, Oxygen and Nutrient Supply, and Metabolic Microenvironment of Human Tumors: A Review," Cancer Res. 49:6449-6465 (1989).
Hoes, C.J.T. et al., "Development of Macromolecular Prodrugs of the Antitumor Antibiotic Adriamycin," Makromol. Chem. Suppl. 9:175-178 (1985).
Hoes, C.J.T. et al., "Biological Properties of Adriamycin Bound to Biodegradable Polymeric Carriers," J. Controlled Rel. 23:37-54 (1993).
Nukui, M. et al., "Association of Macromolecular Prodrugs Consisting of Adriamycin Bound to Poly(L-glutamic acid)," Makromol. Chem. 192:2925-2942 (1991).
Takizawa, A., et al., "Solubilities of Polypeptides with Hydrophobic and Negatively Charnged Side-Chains into Cationic Artificial Membrane Vesicles," Colloid & Polymer Sci. 265:31-36 (1987).
Anderson, D.C. et al., "Enhanced In Vitro Tumor cell Retention and Internalization of Antibody Derivatized with Synthetic Peptides," Bioconjugate Chem. 4:10-18 (1993).
Bongartz, J.-P. et al., "Improved Biological Activity of Antisense Oligonucleotides Conjugated to a Fusogenic Peptide," Nuc. Acids Res. 22(22) :4681-4688 (1994).
Fattal, E. et al., "Pore-Forming Peptides Induce Rapid Phospholipid Flip-Flop in Membranes," Biochemistry 33:6721-6731 (1994).
Haensler, J., and Szoka, F.C., Jr., "Polyamidoamine Cascade Polymers Mediate Efficient Transfection of Cells in Culture," Bioconjugate Chem. 4:372-379 (1993).
Parente, R.A. et al., "Association of a pH-Sensitive Peptide with Membrane Vesicles: Role of Amino Acid Sequence," Biochemistry 29:8713-8719 (1990a).
Parente, R.A. et al., "Mechanism of Leakage of Phospholipid Vesicle Contents Induced by the Peptide GALA," Biochemistry 29:8720-8728 (1990b).
Plank, C. et al., "The Influence of Endosome-Disruptive Peptides on Gene Transfer Using Synthetic Virus-Like Gene Transfer Systems," J. Biol. Chem. 269(17):12918-12924 (1994).
Subbarao, N.K. et al., "pH-Dependent Bilayer Destabilization by an Amphipathic Peptide," Biochemistry 26:2965-2972 (1987).
Summerton James E.
Weller Dwight D.
AVI BioPharma Inc.
Channavajjala L.
Gorthey LeeAnn
Page Thurman K.
LandOfFree
Polymer composition for delivering substances in living organism does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polymer composition for delivering substances in living organism, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymer composition for delivering substances in living organism will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-682999