Polymer composition for controlled release of active ingredients

Details Polymer composition for controlled release of active ingredients Polymer composition for controlled release of active ingredients

1996-03-14

1998-12-22

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424457, 424484, 424486, A61F 200, A61K 952

Patent

active

058515461

ABSTRACT:
The present invention provides a polymer for the controlled release of a pendent chain linked active ingredient, and a process for the preparation of such a polymer for the controlled release of an active ingredient in response to pH. The process involves selecting a vinyl monomer to which the active ingredient molecule is covalently linked through a pendent group, and selecting monomers bearing catalytic groups. The active ingredient-bearing monomer and the catalytic group-containing monomer are brought in juxtaposition either by complexation or molecular imprinting, and then polymerized with a hydrophilic monomer and crosslinker under an inert atmosphere with a suitable polymerization initiator.

REFERENCES:
patent: 4071508 (1978-01-01), Steckler
patent: 4177056 (1979-12-01), Mueller et al.
patent: 4304591 (1981-12-01), Mueller et al.
patent: 4931279 (1990-06-01), Bawa et al.
Agyilirah, G.A., & Banker, G.S., in Polymers for Controlled Drug Delivery, CRC Press, Chapter 3 (1991).
Akashi, M., Beppu, K., Kikuchi, I., and Miyauchi, N., J. Macromo. Sci. (Chem.) A. 23:1233 (1986).
Chaves, M.S., and Arranz, F.,Makromol. Chem. 189:2269 (1988).
Fitch, R.M., Gajria, C., and Tarcha, P.J., J. Colloid. Interface. Sci. 71:107 (1979).
Saffran, M., Kumar, G.S., Savariar, C., and Burnham, J.C., Science 233:1081 (1988).
Shah, S.S., Kulkarni, M.G., & Mashelkar, R.A., J. Appl. Polym. Sci. 41:2437 (1990).
Siegel, R.A., Falamarzian, M., Firestone, B.A. and Moxley, B.C., J. Controlled Release8:179 (1986).
Yean, L. , Bunel, C. and Varian, J.P., Makromol. Chem., 191:1119 (1990).
Wilken, L.O., Kochlar, M.M., Bennett, D.P., and Cosgrove, F.P., J. Pharm. Sci. 51:484 (1962).

Affiliated with

Also associated with

Rating

Polymer composition for controlled release of active ingredients does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymer composition for controlled release of active ingredients, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymer composition for controlled release of active ingredients will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2043427