Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1988-02-29
1990-02-06
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424422, 424469, 424486, 424487, A61F 200
Patent
active
048987344
ABSTRACT:
The present invention is a method to produce novel composites based on microcapsules or microspheres embedded in contiuous polymeric matrices. Both non-bioerodible and erodible polymers can be used. Material can be incorporated into the microcapsules or microspheres for subsequent release. In one embodiment of the present invention, spheres are homogeneously dispersed in a polymer matrix and then forced to release their contents by exposure to temperature, light or ultrasound. Alternatively, polymers which degrade as a function of time or hydrolysis can be used for controlled releases. The polymer composites have completely different properties from either a continuous polymer matrix or microcapsules or microspheres and are therefore useful for a wide variety of applications. When carbon tetrachloride is the incorporated material, the film is useful as a flame retarding device. When foaming agents are used, especially UV or heat sensitive materials, gas can be evolved inside each capsul
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Edelman Elazar
Langer Robert S.
Mathiowitz Edith
Warshawsky Abraham
Massachusetts Institute of Technology
Page Thurman K.
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