Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-03-25
1992-11-10
Cashion, Jr., Merrell C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 18, 530331, 530323, 525 541, A61K 3700, A61K 3702, C07K 500, C07K 700
Patent
active
051623072
ABSTRACT:
Pharmaceutical compositions and methods of inhibiting the enzyme elastase and increasing the biological half-life and/or potency in terms of inhibitory activity of the enzyme elastase of peptide compounds is achieved by use of a polymer of the formula P--(L--R).sub.q wherein P is a polymer containing at least one unit of the formula (A.sub.n B.sub.n) wherein A.sub.n B.sub.n is substantially nonbiodegradable, and has an average molecular weight of about 1,000 to 5,000 daltons, L is a covalent bond or a linker group and R is a peptide.
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Agha Bushra J.
Banks William R.
Digenis George A.
Rypacke Frantisek
Board of Trustees of the University of Kentucky
Cashion Jr. Merrell C.
Czechoslovak Academy of Sciences
Davenport A. M.
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