Polyketides and their synthesis

Details Polyketides and their synthesis Polyketides and their synthesis

2007-04-03

2007-04-03

Peselev, Elli (Department: 1623)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C536S007200

Reexamination Certificate

active

10782257

ABSTRACT:
A polyketide synthase (“PKS”) of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.

REFERENCES:
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patent: WO 98/01546 (1998-01-01), None
patent: WO 98/01571 (1998-01-01), None
patent: WO 98/01571 (1998-01-01), None
patent: WO 98/49315 (1998-11-01), None
patent: WO 99/35157 (1999-07-01), None
Lin, L. et al., “Biosynthesis of 2-Nor-6-deoxyerythronolide B by Rationally Designed Domain Substitution”; Journal of The American Chemical Society, 119(43): 10553-10554 (1997).

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