Polyketides and antibiotics produced by combinatorial...

Details Polyketides and antibiotics produced by combinatorial... Polyketides and antibiotics produced by combinatorial...

2006-10-02

2010-06-22

Peselev, Elli (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C549S271000

Reexamination Certificate

active

07741456

ABSTRACT:
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.

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