Polyketide synthase enzymes and recombinant DNA constructs there

Details Polyketide synthase enzymes and recombinant DNA constructs there Polyketide synthase enzymes and recombinant DNA constructs there

1998-09-16

2000-11-21

Achutamurthy, Ponnathapu

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 237, 435183, 435189, 4352523, 4353201, C12N 1552, C12N 1531, C12N 1563, C12N 1570, C12N 1574

Patent

active

061505137

ABSTRACT:
Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the neuroimmunophilin FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application in agriculture, medicine, and animal health.

REFERENCES:
patent: 4874748 (1989-10-01), Katz et al.
patent: 5063155 (1991-11-01), Cox et al.
patent: 5098837 (1992-03-01), Beckmann et al.
patent: 5116756 (1992-05-01), Dumont et al.
patent: 5149639 (1992-09-01), Katz et al.
patent: 5672491 (1997-09-01), Khosla et al.
patent: 5712146 (1998-01-01), Khosla et al.
patent: 5712496 (1998-01-01), Takahashi et al.
patent: 5824513 (1998-10-01), Donadio et al.
patent: 5876991 (1999-03-01), DeHoff et al.
Caffrey et al, FEBS Letters 304:205 (1992).
Fu et al, Biochemistry 33:9321-9326 (1994).
McDaniel et al., Science 262:1546-1550 (1993).
Motamedi et al., "Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506", Eur. J. Biochem., 244, pp. 74-80, (1997).
Rohr, Angew. Chem. Int. Ed. Engl. 34(8):881-888 (1995).
Schwecke et al., "The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin", Proc. Nat'l Acad. Sci. USA 92 (Aug. 1995), pp. 7839-7843.

Affiliated with

Also associated with

Rating

Polyketide synthase enzymes and recombinant DNA constructs there does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyketide synthase enzymes and recombinant DNA constructs there, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyketide synthase enzymes and recombinant DNA constructs there will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1258628