Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1998-05-13
2000-05-16
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 15, 435 29, 536 72, 514 29, C12Q 100, C12Q 148, C12Q 102, C07H 1708
Patent
active
060635614
ABSTRACT:
The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, -Et, and/or --OH and the ethyl side-chain has been substituted with hydroxymethyl or dihydroxycyclohexylmethyl side-chains. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.
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Kakavas Stephan J.
Katz Leonard
Pereda-Lopez Ana
Ruan Xiaoan
Stassi Diane L.
Abbott Laboratories
Casuto Dianne
Leary Louise N.
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