Polyketide-associated sugar biosynthesis genes

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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435200, 435227, 435228, 435231, 4352523, 43525235, 4353201, 435325, 435419, 536 232, C12N 120, C12N 900, C07H 2104

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active

059981946

ABSTRACT:
The present invention provides isolated polynucleotides from Saccharomyces erythraea that encode enzymes involved in the biosynthesis of polyketide-associated sugars. Methods of using the polynucleotides to produce novel glycosylation modified polyketides are also provided.

REFERENCES:
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Mol Gen Genet, Haydock, et al., 1991, vol. 230:120-128, "Cloning and Sequence Analysis of Genes Involved in Erythromycin Biosynthesis in Saccharopolyspora Eryhtraea: Sequence Similarities Between EryG and A Family of S-Adenosylmethionine-Dependent Methyltransferases".
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