Polyisoprenyl phosphate stable analogs for regulation of neutrop

Details Polyisoprenyl phosphate stable analogs for regulation of neutrop Polyisoprenyl phosphate stable analogs for regulation of neutrop

1997-04-04

1999-12-28

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514106, 514107, 514108, 558152, 558155, A61K 3166, C07F 906, C07F 908, C07F 924, C07F 940

Patent

active

060082054

ABSTRACT:
The present invention is directed to presqualene diphosphate (PSDP) analogs having an active region of natural PSDP and a metabolic transformation region resistant to rapid intracellular inactivation in vivo. For example, PSDP and its stable analogs can inhibit neutrophil signal transduction events in cellular activation that result in the generation of active oxygen species, regulation of leukocyte adherence, both homotypic (leukocyte-leukocyte) or heterotypic adherence with leukocytes and epithelial cells of mucosal origin or endothelial cells of vascular origin. These analogs can also be used to regulate leukocyte-dependent tissue injury.

REFERENCES:
Database CAPLUS on STN.RTM. International, Chemical Abstracts Service, (Columbus, Ohio), Accession No. 1989:227656; Poulter, C.D. et al. Journal of the American Chemical Society 1989, 111(10), 3734-3739.
Database CAPLUS on STN.RTM. International, Chemical Abstracts Service, (Columbus, Ohio), Accession No. 1988:507228; Davisson, V.J. et al. Bioorganic Chemistry 1988, 16(2), 111-123.
Database CAPLUS on STN.RTM. International, Chemical Abstracts Service, (Columbus, Ohio), Accession No. 1979:1766; Altman, L.J. et al. Journal of the American Chemical Society, 1978, 100(19), 6174-6182.
Database CAPLUS on STN.RTM. International, Chemical Abstracts Service, (Columbus, Ohio), Accession No. 1969:78196; Rilling H.C. et al. Journal of the American Chemical Society, 1969, 91(4), 1041-1042.
Levy, B.D. et al. "Plyisoprenyl Phosphates in Intracellular Signalling" Nature 389:985-990 (1997).
Welbourn, et al., Brit. J. Surg.; 78:651-655 (1991).
R. B. Silverman, (1992), "The Organic Chemistry of Drug Design and Drug Action", Academic Press, Chp. 8.
Jarstfer, M.B., et al., J. Am. Chem. Soc., 118, 13089 (1996).
Ortiz de Montellano, P. R., et al., Biochemistry, 16, 2680 (1977).
Jarstfer, et al., J. Am. Chem. Soc., 118, 13089 (1996).
Cohen L. H., et al., Biochem. Pharmacol., 49(6), 839 (1995).
Poulter C. D., Rilling H. C. in Biosynthesis of Isoprenoid Compounds (1981), vol. 1, Chap. 8, 413.
Corey E. J., Volante R. P., J. Am. Chem. Soc., 98, 1291 (1975).
Coates R. M., Robinson W. H., J. Am. Chem. Soc., 93, 1785 (1971).
Goody R. S., Eckstein F., J. Am. Chem. Soc., 93,6252. (1971).
Kornforth R, Popjak G., Methods Enzymol., 15, 382 (1969).
House H. O., Blankley C. J., J. Org. Chem., 33, 53 (1968).
Berge et al. (1977) "Pharmaceutical Salts", J. Pharm. Sci. 66:1-19.
Serhan, C.N., Haeggstrom, J.Z. & Leslie, C.C. FASEB J. 10:1147-1158 (1996).
Weismann, G., Smolen, J.E. & Korchak, H.M.N. Engl. J. Med. 303, 27-34 (1980).
Adair, W.L. & Keller, R.K., Methods Enzymol. 111, 201-215 (1985).
Van Dessel, G.A.F., Lagrou, A.R. Hilderson, H.J.J. & Dierick, W.S.H. In: CRC Handbook of Chromatography (eds Mukherjee, K.D., Weber, N. & Sherma, J.) 321-337 (CRC Press, Boca Raton, 1993).
McPhail, L.C., Shirley, P.S., Clayton, C.C. & Snyderman, R.J. Clin Invest. 75, 1735-1739 (1985).
Agwu, D.E., McPhail, L.C., Sozzani, S., Bass, D.A. & McCall, C.E.J. Clin. Invest. 88, 531-539 (1991).
Farnsworth, C.C., Gelb, M.H. & Glomset, J.A. Science 247, 320-322 (1990).
Popjak, G., Edmond, J. Clifford, K. & Williams, V.J., Biol. Chem. 244, 1897-1918 (1969).
Epstein, W.W. & Rilling, H.C., J. Biol. Chem. 245, 4597-4605 (1970).
Chen, P.S., et al., Anal. Chem. 28, 1756-1758 (1956).
Goldstein, J.L. & Brown, M.S., Nature 343, 425-430 (1990).
Mookhtiar, K.A., Kalinowski, S.S., Zhang, D. & Poulter, C.D., J. Biol. Chem. 269, 11201-11207 (1994).
Shecter. I., Fogelman, A.M. & Popjak, G. J., Lipid Res. 21, 277-283 (1980).
Philips, M.R., Pillinger, M.H., Volker, C., Rosenfield, M.G., Weissmann, G. & Stock, J.B., Science 259, 977-980 (1992).
Baggiolini, M., Boulay, F., Badwey, J.A. & Curnutte, J.T., FASEB J. 7, 10040-1010 (1993).
Gomez-Cambronero, J. & Sha'afi, R.I. in Cell-Cell Interactions In The Release of Inflammatory Mediators. (eds Wong, P. Y-K. & Serhan, C.N.) 35-71 (Plenum Press, New York, (1991).
Scheer, A. & Gierschik, P., Biochemistry. 34, 4952-4961 (1995).
Bromberg, Y. & Pick, E., Cell. Immunol. 88, 213-221 (1984).
Tou, J. & Dola, T., Lipids 30, 373-381 (1995).
Fiore, S., Nicolaou, K.C., Caulfield, T., Kataoka, H. & Serhan, C.N.,Biochem. J. 266, 25-31 (1990).

Affiliated with

Also associated with

Rating

Polyisoprenyl phosphate stable analogs for regulation of neutrop does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyisoprenyl phosphate stable analogs for regulation of neutrop, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyisoprenyl phosphate stable analogs for regulation of neutrop will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2382511