Polyiodinated triglyceride analogs as radiologic agents

Details Polyiodinated triglyceride analogs as radiologic agents Polyiodinated triglyceride analogs as radiologic agents

1985-09-10

1989-10-10

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

2604107, 560 47, 560107, 560106, A61K 4902, C11C 302

Patent

active

048730750

ABSTRACT:
Novel iodinated arylaliphatic triglyceride analogs, as radiologic agents are liver and hepatocyte site-specific. The triglyceride backbone structure is preferably 1,3-disubstituted or 1,2,3-trisubstituted with, in some embodiments, a 3-substituted-2,4,6-triiodophenyl aliphatic chain wherein the chain has a structure similar to naturally occurring fatty acids. In another embodiment, a monoiodophenyl aliphatic chain is utilized. Any position remaining on the triglyceride backbone is substituted with a saturated or unsaturated aliphatic hydrocarbon chain of the type found in naturally occurring fatty acids. The triglyceride analogs can be radioiodinated. In a preferred embodiment, a lipid emulsion is provided as the carrier vehicle.

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Longino, et al., Biodistribution of a New Lipid-Soluble CT Contrast Agent, Investigative Radiology, vol. 18, No. 3, pp. 275-279 (1983).

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