Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1989-05-30
1990-09-18
Maples, John S.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
424 11, 252312, C11C 302, A61K 4904
Patent
active
049577298
ABSTRACT:
Novel iodinated arylaliphatic triglyceride analogs as radiologic agents are liver and hepatocyte site-specific. The triglyceride backbone structure is preferably 1,3-disubstituted or 1,2,3-trisubstituted with, in some embodiments, a 3-substituted-2,4,6-triiodophenyl aliphatic chain wherein the chain has a structure similar to naturally occuring fatty acids. In another embodiment, a monoiodophenyl aliphatic chain is utilized. Any position remaining on the triglyceride backbone is substituted with a saturated or unsaturated aliphatic hydrocarbon chain of the type found in naturally occurring fatty acids. The triglyceride analogs can be radioiodinated. In a preferred embodiment, a lipid emulsion is provided as the carrier vehicle.
REFERENCES:
patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4571332 (1986-02-01), Schroit et al.
patent: 4708861 (1987-11-01), Popescu et al.
patent: 4873075 (1989-10-01), Counsell et al.
Abstract No. 29, 186th ACS National Meeting, Division of Medicinal Chemistry, 8/28-9/2/83.
Seevers, R. H. et al., "Potential Tumor or Organ-Imaging Agents, 23, Sterol Esters of Iopanoic Acids", J. Med. Chem, vol. 25, pp. 1500-1503 (1982).
Damle, N. S. et al., "Potential Tumor or Organ Imaging Agent XXIV: Chylomicron Remnants as Carriers for Hepatographic Agents", J. Pharm. Sci., vol. 72, No. 8, pp. 898-901 (1983).
Counsell Raymond E.
Longino Marc A.
Schwendner Susan P.
Weichert Jamey P.
Harris Cynthia
Maples John S.
The University of Michigan
LandOfFree
Polyiodinated triglyceride analogs as radiologic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polyiodinated triglyceride analogs as radiologic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyiodinated triglyceride analogs as radiologic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1571581