Polyiodinated triglyceride analogs as radiologic agents

Details Polyiodinated triglyceride analogs as radiologic agents Polyiodinated triglyceride analogs as radiologic agents

1990-04-20

1992-03-03

Dees, Jose G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604107, C11C 312

Patent

active

050930427

ABSTRACT:
Novel iodinated arylaliphatic triglyceride analogs as radiologic agents are liver and hepatocyte site-specific. The triglyceride backbone structure is preferably 1,3-disubstituted or 1,2,3-trisubstituted with, in some embodiments, a 3-substituted-2,4,6-triiodophenyl aliphatic chain wherein the chain has a structure similar to naturally occurring fatty acids. In another embodiment, a monoiodophenyl aliphatic chain is utilized. Any position remaining on the triglyceride backbone is substituted with a saturated or unsaturated aliphatic hydrocarbon chain of the type found in naturally occurring fatty acids. The triglyceride analogs can be radioiodinated. In a preferred embodiment, a lipid emulsion is provided as the carrier vehicle.

REFERENCES:
patent: 3144479 (1964-08-01), Obendorf et al.
Weichert et al., J Medicinal Chemistry, vol. 29, pp. 2457-2465.
ACS Abstract, 186th ACS National Meeting.

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