Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent
Patent
1994-06-20
1995-11-14
Dees, Jose G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
X-ray contrast imaging agent
560 47, 560 83, A61K 4904
Patent
active
054664330
ABSTRACT:
Compounds having the structure ##STR1## wherein Z--COO).sub.m is the residue of a polyiodinated aromatic acid; m is 1, 2, 3 or 4;
n is an integer from 1 to 20;
R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;
R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; and
R.sup.5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl;
are useful as contrast agents in x-ray imaging compositions and methods.
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patent: 3317569 (1967-05-01), Larsen et al.
patent: 4924009 (1990-05-01), Neckers et al.
patent: 5322679 (1994-06-01), Bacon et al.
CA 109:128247, 1987.
CA 107:133706, 1986.
CA 106:83870, 1985.
Obendorf, W., Chem. Abstract, 57:4603i (1962)
Siggens et al, J. Med. Chem., 8(5), pp. 728-730 (1965).
Bacon Edward R.
Daum Sol J.
Spara Paul P.
Barts Samuel L.
Dees Jos,e G.
Eastman Kodak Company
Rosenstein Arthur H.
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