Polyhydroxyphenylchromanones

Details Polyhydroxyphenylchromanones Polyhydroxyphenylchromanones

1977-05-02

1978-03-28

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Lymphokine

424195, 424283, A61K 3179, A61K 3578, A61K 3135

Patent

active

040815293

ABSTRACT:
A process is described for producing a pharmaceutical product comprising a polyhydroxyphenyl chromanone obtainable from seeds of Silybum marianum which comprises forming a solution comprising said polyhydroxyphenyl chromanone and polyvinylpyrrolidone of molecular weight in the range from 3,000 to 40,000 in a solvent comprising water and a water-soluble organic solvent, the weight ratio of polyvinylpyrrolidone to polyhydroxyphenyl chromanone being from 0.5:1 to 4:1, and lyophilising said solution. Products may be so produced possessing excellent stability and which may be readily solubilised in aqueous media.

REFERENCES:
patent: 3089818 (1963-05-01), Stone
patent: 3673163 (1972-06-01), Walkling
Remington's Pharm. Sci., 15th Ed. (1975), Mack Publishing Co., Easton, Pa., pp. 1361 and 1245 and 1252.

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