Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-08-23
1991-11-12
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514256, 514316, 514325, 514326, 514329, 514330, 514377, 514380, 514397, 514398, 514399, 514400, 514444, 514447, 514448, 514471, 514472, 514487, 514489, 514490, 514595, 514596, 514598, 514616, 514617, 514624, 514625, 514627, 514630, 544 59, 544155, 544162, 544163, 544390, 546207, 546208, 546209, 546210, 546225, 546226, 548215, 548240, 548343, 548492, 548567, 549 59, 549 60, 549 72, 549487, 558422, 560 27, 560 29, 564 48, 564 55, 564 56, 564157, 564184, 564189, 564190, 564202, 564207, 564220, A61K 315
Patent
active
050648276
ABSTRACT:
Compounds of the present invention, are represented by the general formula ##STR1## wherein R.sub.1 group which may be alkyl of from 1 to about 6 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 10 carbon atoms, alkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms, halogen, acetamido, amino, nitro, alkylamino of from 1 to about 6 carbon atoms, hydroxy, hydroxyalkyl of from 1 to about 6 carbon atoms, cyano or arylalkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms R.sub.2, R.sub.3 and R.sub.4 are hydrogen or hydroxyl groups or the combination of either hydrogen or hydroxyl groups; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NHCOR.sub.5, --NHCONR.sub.5 R.sub.6, or --NHCOOR.sub.5 wherein R.sub.5 and R.sub.6 may be the same or different and represent hydrogen, alkyl of from 1 to about 6 carbon atoms, alkoxyalkyl wherein the alkyl groups may be the same or different and contain from 1 to about 6 carbon atoms, cycloalkyl of from 3 to about 8 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 6 carbon atoms, phenyl which may be unsubstituted or substituted with alkyl of 1 to 6 carbon atoms; furanyl, thiophenyl, imidazole, oxazole or indole, aralkyl wherein the alkyl group contains from 1 to about 6 carbon atoms and the aryl group represents phenyl unsubstituted or substituted with alkyl of from 1 to about 6 carbon atoms, or R.sub.5 and R.sub.6 may together with N form a pyrrolidine, piperidine, piperazine, morpholine or thiomorpholine ring and except that R.sub.5 is not hydrogen when B is --NHCOOR.sub.5 ; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment or prophylaxis of cardiac disorders or in the treatment of glaucoma.
REFERENCES:
patent: 3996382 (1976-12-01), Berntsson et al.
patent: 4593039 (1986-06-01), Baldwin et al.
patent: 4880805 (1989-11-01), Bohm et al.
patent: 4959390 (1990-09-01), Patil
Mai Khuong H. X.
Matier William L.
Patil Ghanshyam
Du Pont Merck Pharmaceutical Company
Fato Gildo E.
Raymond Richard L.
Treanor Susan P.
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