Polyhydroxy phenols and their use in binding p-selectin

Details Polyhydroxy phenols and their use in binding p-selectin Polyhydroxy phenols and their use in binding p-selectin

2007-09-25

2007-09-25

Richter, Johann (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C558S271000, C514S002600, C514S419000, C514S469000, C514S561000, C424S001210, C548S469000

Reexamination Certificate

active

10558495

ABSTRACT:
Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.

REFERENCES:
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Yamaguchi, K. et al., “Inhibitory Effects of (-)-epigallocatechin Gallate on the Life Cycle of Human Immunodeficiency Virus Type 1 (HIV-1)”,Antiviral Research, 2002, vol. 53, pp. 19-34.

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