Polyhydroxy diamine surfactants and their use in gene transfer

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S018700, C514S04400A, C424S450000

Reexamination Certificate

active

07005300

ABSTRACT:
The use of carbohydrate-based surfactant compounds having the general formula (I):wherein Y1and Y2, which may be the same or different, are carbohydrate groups;R1and R2, which may be the same or different, are selected from:a) hydrogen;b) C(1-24)alkyl group;c) C(1-24)alkyl carboxy group; ord) a carbon chain of 2 to 24 carbon atoms having one or more carbon/carbon double bonds,and n is from 1 to 10;for facilitating the transfer of DNA or RNA polynucleotides, or analogs thereof, into a eukaryotic or prokaryotic cell in vivo or in vitro.New carbohydrate-based surfactant compounds are also disclosed.

REFERENCES:
Gleave, M. et al., “Clusterin and IGFBPs as Antisense Targets in Prostate Cancer”, 2003, Ann. N.Y. Acad. Sci.Vol. 1002: pp. 95-104.
Juengst, E.T., “What next for human gene therapy?”, 2003, BMJ, vol. 326: pp. 1410-1411.
Berzofsky, J.A., et al., “Progress on new vacine strategies for the immunotherapy and prevention of cancer”, 2004, J. Clin. Invest., vol. 113: pp. 1515-1525.
Dang, C.V., et al., “Gene Therapy and Translational Cancer Research”, 1999, Clin. Cancer Res., vol. 5: pp. 471-474.
Restifo, N.P. et al., “The promise of nucleic acid vaccines”. 2000, Gene Therapy, vol. 7:, pp. 89-92.
Madigan, M.T. et al., in “Biology of Macroorganisms”, 1997, Eighth Edition, Prentice Hall, pp. 323-324.
Sambrook et al., in “Molecular Cloning: A Laboratory Manual”, 1995, Cold Spring Harbor Laboratory Press, pp. 1.74-1.75.
Gao, et al., “Cationic Liposome-Mediated Gene Transfer”.Gene Therapy, GB, MacMillan Press Ltd., Basingstoke, 2(10): 710-722 (Dec. 1, 1995).
Pestman, et al., “Nonionic Bolaamphiphiles and Gemini Surfactants Based on Carbohydrates”,Langmuir, 13: 6857-6860 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polyhydroxy diamine surfactants and their use in gene transfer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyhydroxy diamine surfactants and their use in gene transfer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyhydroxy diamine surfactants and their use in gene transfer will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3672595

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.