Polyhydroxy curcumins having antioxidant activity

Details Polyhydroxy curcumins having antioxidant activity Polyhydroxy curcumins having antioxidant activity

2005-05-31

2005-05-31

Barts, Samuel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S333000, C568S729000

Reexamination Certificate

active

06900356

ABSTRACT:
This invention relates to novel polyhydroxy curcumins of the formula (I), wherein R and R1may be same or different and are selected from H, OH and OCH3. This invention also includes a process for synthesising the above polyhydroxy curcumins by reacting substituted aromatic alhehydes with a diketone in the presence of boron oxide, alkyl borate and a primary or secondary amine catalyst. If desired, the resulting compounds can be deprotected by known means. These compounds are used as anti-oxidants.

REFERENCES:
patent: 5679864 (1997-10-01), Krackov et al.
Artico, Marino, et al.; “Geometrically and Conformationally Restrained Cinnamoyl Compounds as Inhibitors of HIV-1 Integrase: Synthesis, Biological Evaluation, and Molecular Modeling;”J. Medical Chem,41, pp. 3948-3960 (1998).
PCT International Preliminary Examination Report (5 pages total), which was completed on Apr. 23, 2003, for PCT Application No. PCT/IN01/00090.

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