Polyhydro derivatives of tylosine and process for their preparat

Details Polyhydro derivatives of tylosine and process for their preparat Polyhydro derivatives of tylosine and process for their preparat

1997-10-28

1999-07-13

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, 536 72, 536 74, A61K 7131

Patent

active

059226846

ABSTRACT:
The invention relates to 13-hydroxy-tylosine derivatives, novel semisynthetic antibiotics from the class of macrolides, and to a process for the preparation thereof. According to the present invention by a reductive opening of the oxirane ring of tylosine 13-hydroxy compounds are obtained, which are then subjected to a hydrogenation of the double bond and then 13-hydroxy dihydro or tetrahydro compounds are subjected to an oximation reaction or 13-hydroxy oximes are subjected to the hydrogenation of the double bond.

REFERENCES:
patent: 4680386 (1987-07-01), Morimoto et al.
patent: 5023240 (1991-06-01), Narandja et al.

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