Polyhalogeno-steroids

Details Polyhalogeno-steroids Polyhalogeno-steroids

1984-04-20

1986-10-28

Roberts, Eibert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

26039745, A61K 3156

Patent

active

046199217

ABSTRACT:
Novel 6.alpha.,9.alpha.,21-trihalogeno-11.beta.-hydroxy-16.alpha. or 16.beta.-methyl-17.alpha.-propionyloxy-pregn-4-ene-3,20-dione compounds of the formula ##STR1## in which X represents chlorine or flourine, R represents the group --CH.sub.2 CH--, --CH.dbd.CH-- or --CH.dbd.CCl--, the chlorine atom being in the positon 2 of the steroid numbering, and in which the 16-methyl radical is .alpha.- or .beta.-oriented, are useful pharmaceuticals, especially anti-inflammatory agents for topical administration.

REFERENCES:
patent: 3652554 (1972-03-01), Anner et al.
patent: 3718673 (1973-02-01), Ripka
patent: 3992422 (1976-11-01), Green
patent: 4018918 (1977-04-01), Ayer et al.

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