Polyglycerol and lactose compositions for the protection of...

Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or...

Reexamination Certificate

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C435S001200, C435S001300

Reexamination Certificate

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06949335

ABSTRACT:
Polyglycerol, lactose, and a combination of polyglycerol and lactose are effective at preserving cells, tissues, and organs from damage due to hypothermic, ischemic, or other metabolic impairment, and a mixture of polyglycerol plus lactose is particularly useful for the hypothermic storage of cells, tissues, and organs. The mixture of polyglycerol and lactose can be further improved by the addition of chondroitin sulfate, chlorpromazine, calcium, citrate, glutathione, adenine, glucose, magnesium, and a pH buffer.

REFERENCES:
patent: 5145769 (1992-09-01), McNally et al.
patent: 5158867 (1992-10-01), McNally et al.
patent: 5306711 (1994-04-01), Andrews
patent: 6194137 (2001-02-01), Khirabadi et al.
patent: 6616858 (2003-09-01), Fahy et al.
Klebe et al., “Identification of new cryoprotective agents for cultured mammalian cells”, In Vitro 19 (3): 167-170 (1983).
Al-Abdulla, Nael A. B.Sc. et al., The Effects of Supercooling Chemicals on Myocardial Ultrastructure: A Transmission Electron Microscopy Case Study,Connecticut Medicine, 59: 387-399, 1995.
Kaufman, Herbert E. et al., Optisol Corneal Storage Medium,Arch Ophthalmol,109: 864-868, 1991.
Toledo-Pereyra, Luis H. and Ramakrishnan, Vellore R., Effect of Chondroitin Sulfate on the Prolongation of Kidney Allograft Survival,Transplantation, 27 (6): 427-429, 1979.
Pegg, D.E., Jacobsen, I.A., Halasz, N.A., Organ Presevation—Basic and Applied Aspects,MTP Press,Lancaster, 1982, pp. 323-324.
Khirabadi, Bijan S. and Fahy, Gregory M., Cryopreservation of the Mammalian Kidney. 1. Transplantation of Rabbit Kidneys Perfused with EC and RPS-2 at 2-4° C1,Cryobiology,31: 10-25, 1994.
Fahy, Gregory M. et al., Cell Biology of Trauma, J.J. Lemasters and C. Oliver (Eds.),CRC Press,1995, pp. 333-356.

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