Polyfunctional epoxides and halohydrins used as bridging groups

Details Polyfunctional epoxides and halohydrins used as bridging groups Polyfunctional epoxides and halohydrins used as bridging groups

1979-10-12

1981-09-01

Cannon, James C.

Chemistry: physical processes

Physical processes

Crystallization

8181, 8666, 8DIG8, 232303, 23902, 422 71, 424 1, 424 15, 424 12, 435 6, 435172, 536 43, 536 85, C08B 1120, C08B 1506, G01N 3122, G01N 3316

Patent

active

042869641

ABSTRACT:
A process for preparing a derivative of an hydroxyl bearing substrate by reacting an hydroxyl bearing substrate with oxirane bearing molecules to produce an oxirane ring bearing substrate; and reacting the oxirane ring with a substituted primary aromatic amine selected from primary aromatic amine alcohols and primary aromatic amine thiols. Among the compositions so produced is a stable modified hydroxyl bearing substrate or hydroxyl bearing sheet having covalently bonded thereto primary aromatic amines which can be diazotized. The diazotized substrate selectively, covalently binds proteins, polypeptides, peptides, nucleic acids, RNA, single stranded DNA, and nucleic acid hybrids.

REFERENCES:
patent: 3464781 (1969-09-01), Berni et al.
patent: 4139346 (1979-02-01), Rabbani
patent: 4200735 (1980-04-01), Sano et al.
McKelvey et al., J. of Polymer Sci., vol. 11, pp. 1693-1701, (1967).

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