Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Patent
1995-09-27
1999-02-09
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
554103, 554109, 554231, 554108, 564291, 564292, 564293, 568583, 568589, C07C10100
Patent
active
058697152
ABSTRACT:
For use in transporting biologically active species into and through membrane barriers, a cationic amine compound is utilized that has the general structure: ##STR1## wherein R.sub.4 and R.sub.5 are a pair of same or different lipoyl moieties selected from a group consisting of an alkyl, alkenyl, alkynyl, alkanoyl, alkenoyl, or alkynoyl groups and for R.sub.1 R.sub.2, and R.sub.3 at least two are hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl groups or at least one amine bonded halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group or a mixture of at least one halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group and at least one hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl group, and X.sup.- is an anion.
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A Flexible Approach to Synthetic Lipid Ammonium Salts for Polynucleotide Transfection by Bennett et al., Tetrahedron Letters, vol. 36, No. 13, pp. 2207-2210, 1995.
Balasubramaniam Rajiv P.
Bennett Michael J.
Nantz Michael H.
Carr Deborah D
Geist Gary
Ritchey James M.
The Reagents of The University of California
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