Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Reexamination Certificate
2007-11-13
2007-11-13
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
C524S916000
Reexamination Certificate
active
10490969
ABSTRACT:
The inventive polyfunctional biocompatible hydrogel comprises 1.3–15 mass % of acrylamide, 0.004–0.975 mass % of cross-linking agents—N,N′-methylen-bis-acrylamide, 0.004–5.1 mass % of N,N′-ethylen-bis-acrylamide, 0.002–0.45 mass % of poviargol and water up to 100 mass %. Said hydrogel is produced by sopolymerising acrylamide with the cross-linking agents in an aqueous medium in the presence of peroxide polymerisation initiator, the incubation of reaction mixture being carried out in two stages. The first stage is carried out at a temperature ranging from 20 to 90° C. during a time of 2 to 24 hours, the second stage being carried out at a temperature ranging from 107 to 130° C. during a time equal to or less than 2 hours.
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Biopharma Development, Ltd.
Brown & Michaels PC
Hartley Michael G.
Rogers J
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