Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing
Patent
1993-03-05
1995-06-20
Beisner, William H.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
424 9463, 424 9464, 435212, 435219, 435224, 435183, 435940, 435942, C12N 900, C12N 948, C12N 958
Patent
active
054259428
ABSTRACT:
The present invention provides a human polyfuctional protease chracterized in that the protease has unique enzymological and physicochemical properties:
REFERENCES:
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Biological Abstracts, vol. 78, No. 1, 1984, Abstract No. 4750, Phila. PA, US; F. C. Lowe et al.: "Biochemical methods for predicting metstatic ability of prostatic cancer utilizing the Dunning R-3327 rat prostatic adenocarcinoma system as a model".
Biotec., vol. 1, 1987, pp. 119-130, Stuttgart, DE; M. Bahn et al.: "Enzymes for detergents", pp. 119-128.
S. Ferrone et al.: "Handbook of Monoclonal Antibodies", 1985, pp. 131-149, Noyes Publications, Park Ridge, US; Chapter 9: F. Celada et al.: "Monocional antibodies in enzymology".
Cell Structure and Function, vol. 12, No. 6, 1987, p. 601 "A high molecular weight multi-protease complex distributed ubiquitously in a variety of eukaryotic cells".
The Journal of Biological Chemistry, vol. 263, No. 31, No. 5, 1988, pp. 16209-16217 "Proteasomes as 20S ring shaped particles in a variety of eukaryotic cells".
Arrigo, et al. Nature vol. 331 14 Jan. 1988.
Tanaka, et al. J Biological Chemistry vol. 261 No. 32 pp. 15197-15203 1986.
Beisner William H.
Otsuka Pharamceutical Co., Ltd.
Williams Jane A.
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