Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1996-08-26
2000-05-30
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
514 18, 514 19, 548535, 548496, C07K 508
Patent
active
060692324
ABSTRACT:
This invention relates to polyfluoroalkyl tryptophan tripeptides and to compositions containing them. The compounds are highly selective thrombin inhibitors which provide anticoagulant effects useful in the treatment of thrombin conditions and in preventing the coagulation of stored whole blood and blood products.
REFERENCES:
patent: 4061625 (1977-12-01), AfEkenstam et al.
patent: 4216142 (1980-08-01), Ali
patent: 4217269 (1980-08-01), Cole
patent: 4221706 (1980-09-01), Ali et al.
patent: 4247454 (1981-01-01), AfEkenstam et al.
patent: 4275153 (1981-06-01), Gagiulo
patent: 4318904 (1982-03-01), Shaw et al.
patent: 4399065 (1983-08-01), Bajusz et al.
patent: 4450105 (1984-05-01), Nagasawa et al.
patent: 4478745 (1984-10-01), Bajusz et al.
patent: 4607047 (1986-08-01), Debay
patent: 4643991 (1987-02-01), Digenis et al.
patent: 4703036 (1987-10-01), Bajusz et al.
patent: 4720484 (1988-01-01), Vincent
patent: 4762821 (1988-08-01), Nestor
patent: 4816560 (1989-03-01), VErdini et al.
patent: 4816562 (1989-03-01), Nagasawa et al.
patent: 4826814 (1989-05-01), Sawayama et al.
patent: 4880780 (1989-11-01), Trainor et al.
patent: 4929602 (1990-05-01), Harker et al.
patent: 4980349 (1990-12-01), Roger et al.
patent: 5053392 (1991-10-01), Klein et al.
patent: 5391705 (1995-02-01), Neises et al.
Pitzele, Barrett S., J. Med. Chem., 1994, vol. 37, pp. 888-896.
Shuman, Robert T., J. Med. Chem., 1993, vol. 36, pp. 314-319.
Chem. Abst., vol. 110, p. 709, 1989, No. 76058: Angliker, "Synthesis and properties of peptidyl derivatives of arginylfluoromethames" (Biochemical Journal), vol. 256, No. 2, pp. 481-486.
Angeliker et al, Biochem. J. vol. 256, No. 2, pp. 481-486 (1988).
Gelb et al, "Fluoro Ketone Inhibitors of Hydrolytic Enzymes", Biochemistry, vol. 24, No. 8, pp. 1813-1817, (1985).
Sham et al, "Highly potent and specific inhibitors of human renin", FEBS Letters, vol. 220, No. 2, pp. 299-301, 1987.
Chemical Abstracts, vol. 107, 1987, No. 40336Y, p. 758, Stueber, M: Oigopeptidylargininol derivatives and their homologs, there use as antithrombics and agents containing them (Abstract of EP 0 192 138).
Shuman et al, Proceedings of the 12th American Peptide Symposium, pp. 801-802 (1991).
Kolb et al, Tetrahedron Letters vol. 27, No. 14, pp. 1579-1582 (1986).
Kolb et al, Tetrahedron Letters vol. 27, No. 37, pp. 4437-4440 (1986).
Kolb et al, Liebigs Ann. Chem. pp. 1-6 (1990).
Peet, N.P., et al J. Med. Chem. 33, pp. 394-407 (1990).
Neises, B., et al, Journal of the International Society of Thrombosis and Haemostatis, Abstracts p. 1290, (1991).
Ranganathan et al, Nitroethylene: A Stable, Clean and Reactive Agent for Organic Synthesis, J. Org. Chem., 45, pp. 1185-1189 (1980).
Berliner, Lawrence J., et al, "Physical Evidence for an Apolar Binding Site Near the Catalytic Center of Human .alpha.-Thrombin.dagger.", Biochemistry, vol. 16, No. 21, 1977, pp. 4622-4626.
Malikayl et al, Biochemistry, vol. 36, pp. 1034-1040, (1997).
Broersma Robert J.
Burkhart Joseph P.
Malikayl J. Anthony
Peet Norton P.
Hill Jr. Robert J.
Hoechst Marion Roussel Inc.
Lukton David
Payne T. Helen
LandOfFree
Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1911149