Polyethylene-protein conjugates

Details Polyethylene-protein conjugates Polyethylene-protein conjugates

1995-06-01

1998-12-15

Mullis, Jeffrey

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From reactant having a halogen atom or oxygen single bonded...

546300, 546301, C07D21364, C08G 6502, C08G 6526, C08G 6528

Patent

active

058498605

ABSTRACT:
The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein which forms this conjugate.

REFERENCES:
patent: 3607653 (1971-09-01), Ziffer et al.
patent: 3619371 (1971-11-01), Crook et al.
patent: 3639213 (1972-02-01), Ginger et al.
patent: 3645852 (1972-02-01), Axen et al.
patent: 3788948 (1974-01-01), Kagedal et al.
patent: 3959080 (1976-05-01), Orth et al.
patent: 4002531 (1971-01-01), Royer
patent: 4094744 (1978-06-01), Hartdegen, et al.
patent: 4100271 (1978-07-01), Krezanoski
patent: 4179337 (1979-12-01), Davis et al.
patent: 4261973 (1981-04-01), Lee et al.
patent: 4275000 (1981-06-01), Ross
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4310397 (1982-01-01), Kaetsu et al.
patent: 4486344 (1984-12-01), Buckler
patent: 4496689 (1985-01-01), Mitra
patent: 4609546 (1986-09-01), Hirotani
patent: 4640835 (1987-02-01), Shimizu et al.
patent: 4704274 (1987-11-01), Sakuma et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4791192 (1988-12-01), Nakagawa et al.
patent: 4797491 (1989-01-01), Nitecki, et al.
patent: 4810638 (1989-03-01), Albarella et al.
patent: 4818769 (1989-04-01), Numbert et al.
patent: 4847079 (1989-07-01), Kwan
patent: 4847325 (1989-07-01), Shadle, et al.
patent: 4851220 (1989-07-01), Yim et al.
patent: 4871538 (1989-10-01), Yim et al.
patent: 4894226 (1990-01-01), Aldwin et al.
patent: 4902502 (1990-02-01), Nitecki et al.
patent: 4917888 (1990-04-01), Katre et al.
patent: 4935465 (1990-06-01), Garman
patent: 5034514 (1991-07-01), Nitecki, et al.
patent: 5100664 (1992-03-01), Doyle et al.
patent: 5102872 (1992-04-01), Singh et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5214131 (1993-05-01), Sano, et al.
patent: 5382657 (1995-01-01), Karasiewicz et al.
Veronese, et al., Appl. Biochem and Biotech 11:141-152 (1985) "Surface modification proteins."
Arend, et al., J. Clin. Invest. 85(5):1694-1697 (1990) "Biological properties of recombinant human monocyte-derived interleukin-1 receptor antagonist."
Knauf, et al., J. Biol. Chem. 263:15064-15070 (1988) "Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 . . . ".
Ho, et al., Drug Metabolsim and Disposition 14:349-352 (1986) "Clinical pharmacology of polyethylene glycol-asparaginase."
King, et al. Int. Archs. Allergy Appl. Immunol.66(4):439-446 (1986) "Immunologic properties of conjugates of ragweed antigen E with various alkoxypolyethelene . . . "
Nureddin, et al., Biochem. J. 147:71-81 (1975) "Chemical modification of amino guanidini groups."
Abuchowski, et al., Cancer Biochem. Biophys. 7(2):175-186 (1984) "Cancer therapy with chemically modified enzymes . . . ".
Hannum, et al., Nature 343:336-340 (1990) "Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor."
Ohlsson, et al., Nature 348:550-552 (1990) "Interleukin-1 receptor antagonist reduces mortality from endotoxin shock."
Szego, et al., Chem Abs. 101:700 Abstract No. 130594 (1984).
Zalipsky, et al., Polym. Prep. 27(1):1-2 (1986) "Preparation of polyethylene glycol with two different functional groups at the termini."
King, et al., Peptide Protein Res. 16:147-155 (1980) "Preparation of protein conjugates with alkoxypolyethylene glycols."
Hiemenz in Polymer Chemistry, pp. 34-43. Marcel Dekker, 1984.
Fried in Polymer Science and Technology, "1.3 Molecular Weight" pp. 16-18, Prentice Hall, 1995.
Mandelkern in An Introduction to Macromolecules, pp. 19-27. Springer-Verlag, 1983.

Affiliated with

Also associated with

Rating

Polyethylene-protein conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyethylene-protein conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyethylene-protein conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1458972