Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-06-01
1998-08-11
Sayala, Chhaya D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 857, 424 854, 435188, 514 12, 530350, 530403, 530405, 530409, C07K 100, A61K 3819, A61K 3821
Patent
active
057928347
ABSTRACT:
The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein which forms this conjugate.
REFERENCES:
patent: 3607653 (1971-09-01), Ziffer et al.
patent: 3619371 (1971-11-01), Crook et al.
patent: 3639213 (1972-02-01), Ginger et al.
patent: 3645852 (1972-02-01), Axen et al.
patent: 3788948 (1974-01-01), Kagedal et al.
patent: 3959080 (1976-05-01), Orth et al.
patent: 4002531 (1977-01-01), Royer
patent: 4094744 (1978-06-01), Hartelegen et al.
patent: 4100271 (1978-07-01), Krezanoski
patent: 4179337 (1979-12-01), Davis et al.
patent: 4261973 (1981-04-01), Lee et al.
patent: 4275000 (1981-06-01), Ross
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4310397 (1982-01-01), Kaetsu et al.
patent: 4486344 (1984-12-01), Blicker
patent: 4496689 (1985-01-01), Mitra
patent: 4609546 (1986-09-01), Hirotani
patent: 4640835 (1987-02-01), Shimizu et al.
patent: 4704274 (1987-11-01), Sakuma et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4791192 (1988-12-01), Nakagawa et al.
patent: 4797491 (1989-01-01), Nitecki et al.
patent: 4810638 (1989-03-01), Albarella et al.
patent: 4818769 (1989-04-01), Nunberg et al.
patent: 4847079 (1989-07-01), Kwan
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4851220 (1989-07-01), Yim et al.
patent: 4871538 (1989-10-01), Yim et al.
patent: 4894226 (1990-01-01), Aldwin et al.
patent: 4902502 (1990-02-01), Nitecki et al.
patent: 4917888 (1990-04-01), Katre et al.
patent: 4935465 (1990-06-01), Garman
patent: 5034514 (1991-07-01), Nitecki et al.
patent: 5100664 (1992-03-01), Doyle et al.
patent: 5102872 (1992-04-01), Singh et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5153265 (1992-10-01), Shadle et al.
patent: 5214131 (1993-05-01), Sano et al.
patent: 5234903 (1993-08-01), Nho et al.
patent: 5539063 (1996-07-01), Hakimi et al.
patent: 5559213 (1996-09-01), Hakimi et al.
Zalipsky et al., Polym. Prepr., vol. 27(1), pp. 1-2, 1986.
Beauchamp et al., Anal. Biochem., vol. 131, pp. 25-33, 1983.
Zalipslay et al (1986) Polym. Pre. 27(1):1-2.
King et al (1980) Int. J. Protein Peptide Res. 16: 147-155.
Veronese, Applied Biochem. & Biotechnolo. 11:141-152 (1985).
Arend et al., J. Clin. Invest. 88:1694-1697 (1990).
Knauf et al., J. Biological. Chem. 263:15064-15070 (1988).
Ho et al., Drug Metab. and Disposition 14:349-352 (1986).
King et al., Int. Archs. Allergy Appl. Immun. 66:439-446 (1981).
Nureddin et al., Biochem. J. 147:71-81 (1975).
Abuchoski et al., Biochem. Biophys. 7:175-186 (1984).
Eisenberg et al., Nature 343:341-346 (1990).
Ohlsson et al., Nature 348:550-552 (1990).
King et al., Int. Archs. Allergy Appl. Immun. 66:439-446 (1981).
Szego et al., Chem. Abs. 101:700 Abstract No. 13059m (1984).
Hakimi John
Kilian Patricia
Rosen Perry
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
Kreisler Lewis J.
Sayala Chhaya D.
LandOfFree
Polyethylene-protein conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polyethylene-protein conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyethylene-protein conjugates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-389787