Polyethylene glycol-protein compositions which reduce the antige

Details Polyethylene glycol-protein compositions which reduce the antige Polyethylene glycol-protein compositions which reduce the antige

1998-09-24

2000-10-10

Saunders, David

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

424 931, 424 937, 435 11, 435 2, 435325, 435372, A01N 102, A61K 3518, C12N 506

Patent

active

06129912&

ABSTRACT:
The present invention provides a composition of matter, comprising a red blood cell coated a polymeric mixture of polyethylene glycol and albumin. Also provided is a method of blocking blood group antigens on the surface of a red blood cell, comprising the step of contacting said cell with a pharmacologically effective concentration of the composition of the present invention.

REFERENCES:
patent: 5498421 (1996-03-01), Grinstaff et al.
patent: 5908624 (1999-06-01), Scott et al.
Murad, K. et al. Molecular camoflage of antigenic determinants on intact mammalian cell: Possible applications to transfusion medicine. Blood v 88 #10 Suppl 1, p. 444a, Abstract 1765, Nov. 15, 1996.
Monfardini, et al. A branched monomethoxypoly(ethylene glycol) for protein modification. Bioconjugate Chemistry. v6 #1, pp. 62-69, Feb. 13, 1995.

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